Polypharmacy vs No Polypharmacy: Mortality
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
Measures 6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note | Source |
|---|---|---|---|---|---|---|
| Risk in group 1 | 0.0298 | 0.029 | 0.0307 | wilson | ClinicalTrials.gov | |
| Risk in group 2 | 0.0159 | 0.0152 | 0.0167 | wilson | ClinicalTrials.gov | |
| Risk difference, group 1 minus group 2 | 0.0139 | 0.0128 | 0.015 | newcombe hybrid score | ClinicalTrials.gov | |
| Risk ratio, group 1 over group 2 | 1.87 | 1.78 | 1.97 | log | ClinicalTrials.gov | |
| Odds ratio, group 1 over group 2 | 1.9 | 1.8 | 2.01 | log | ClinicalTrials.gov | |
| Number needed to treat, for one more participant with the outcome on Polypharmacy than on No Polypharmacy | 71.9 | 66.6 | 78.3 | from the risk difference interval | ClinicalTrials.gov |
Groups 2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code | Source |
|---|---|---|---|---|---|---|
| Group 1 | Polypharmacy | People taking \>=5 unique prescription drugs in the 3 months prior to surgery~Polypharmacy: Patients who are taking \>=5 unique prescription drugs in the 3 months prior to surgery | 4,356 | 146,029 | OG000 | ClinicalTrials.gov |
| Group 2 | No Polypharmacy | People taking \<5 unique prescription drugs in the 3 months prior to surgery | 1,919 | 120,470 | OG001 | ClinicalTrials.gov |
Outcome 5
| Field | Value | Source |
|---|---|---|
| Type | PRIMARY | ClinicalTrials.gov |
| Title | Mortality | ClinicalTrials.gov |
| Description | death from any cause | ClinicalTrials.gov |
| Time frame | from day of surgery up to 90 days after surgery | ClinicalTrials.gov |
| Population | ClinicalTrials.gov |
Trial 8
| Field | Value | Source |
|---|---|---|
| Title | Polypharmacy and Outcomes After Elective Noncardiac Surgery | ClinicalTrials.gov |
| NCT number | NCT03133182 | ClinicalTrials.gov |
| Phases | ClinicalTrials.gov | |
| Conditions | Polypharmacy, Surgical Procedure, Operative, Morality, Epidemiology | ClinicalTrials.gov |
| Interventions | Polypharmacy | ClinicalTrials.gov |
| Lead sponsor | Ottawa Hospital Research Institute | ClinicalTrials.gov |
| Results first posted | 2025-01-24 | ClinicalTrials.gov |
| Results on ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT03133182?tab=results | ClinicalTrials.gov |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trial-comparisons-2026-03-23-0.1.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57 | ClinicalTrials.gov |
| AACT copy | 2026-03-23 | ClinicalTrials.gov |
| Tables read | outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet | ClinicalTrials.gov |
Release trial-comparisons-2026-03-23-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.