Comparison · NCT03140969-3111f468
QR-110 Low Dose vs QR-110 Mid Dose: Frequency and Severity of Ocular Adverse Events in the Treatment and Contralateral Eyes
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. QR-110 Low Dose vs QR-110 Mid Dose: Frequency and Severity of Ocular Adverse Events in the Treatment and Contralateral Eyes. Trial comparisons, record NCT03140969-3111f468. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03140969-3111f468
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 1 | 0.61 | 1 | wilson | |
| Risk in group 2 | 1 | 0.566 | 1 | wilson | |
| Risk difference, group 1 minus group 2 | 0 | -0.39 | 0.434 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1 | 1 | 1 | log | |
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat | from the risk difference interval | the two groups' risks are equal |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | QR-110 Low Dose | 160/80 μg Cohort | 6 | 6 | OG000 |
| Group 2 | QR-110 Mid Dose | 320/160 μg Cohort | 5 | 5 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Frequency and Severity of Ocular Adverse Events in the Treatment and Contralateral Eyes
- Description
- Time frame
- 1 year
- Population
Source ClinicalTrials.gov
Trial
- Title
- Study to Evaluate QR-110 in Leber's Congenital Amaurosis (LCA) Due to the c.2991+1655A>G Mutation (p.Cys998X) in the CEP290 Gene
- NCT number
- NCT03140969
- Phases
- PHASE1, PHASE2
- Conditions
- Leber's Congenital Amaurosis
- Interventions
- QR-110
- Lead sponsor
- Laboratoires Thea
- Results first posted
- 2022-12-27
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03140969?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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