Comparison · NCT03142334-deaths
Pembrolizumab vs Placebo: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Pembrolizumab vs Placebo: deaths from any cause. Trial comparisons, record NCT03142334-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03142334-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0363 | 0.0231 | 0.0566 | wilson | |
| Risk in group 2 | 0.0663 | 0.0476 | 0.0916 | wilson | |
| Risk difference, group 1 minus group 2 | -0.03 | -0.0585 | -0.00235 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.548 | 0.313 | 0.959 | log | |
| Odds ratio, group 1 over group 2 | 0.531 | 0.295 | 0.956 | log | |
| Number needed to treat, for one fewer death from any cause on Pembrolizumab than on Placebo | 33.4 | 17.1 | 426 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Pembrolizumab | Participants received pembrolizumab 200 mg via intravenous (IV) infusion on Day 1 of each 3-week cycle for up to 17 cycles (up to approximately 1 year). | 18 | 496 | EG000 |
| Group 2 | Placebo | Participants received placebo (saline solution) via IV infusion on Day 1 of each 3-week cycle for up to 17 cycles (up to approximately 1 year). | 33 | 498 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
- Up to approximately 43 months (Database cutoff date 14 Dec 2020).
Source ClinicalTrials.gov
Trial
- Title
- Safety and Efficacy Study of Pembrolizumab (MK-3475) as Monotherapy in the Adjuvant Treatment of Renal Cell Carcinoma Post Nephrectomy (MK-3475-564/KEYNOTE-564)
- NCT number
- NCT03142334
- Phases
- PHASE3
- Conditions
- Renal Cell Carcinoma
- Interventions
- Pembrolizumab, Placebo
- Lead sponsor
- Merck Sharp & Dohme LLC
- Results first posted
- 2021-12-28
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03142334?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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