Comparison · NCT03163446-b8f8ce94
cBSI/R-IE - CF-301 vs cBSI/R-IE - Placebo: Clinical Responders at Day 14 in Patients With cBSI/R-IE
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. cBSI/R-IE - CF-301 vs cBSI/R-IE - Placebo: Clinical Responders at Day 14 in Patients With cBSI/R-IE. Trial comparisons, record NCT03163446-b8f8ce94. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03163446-b8f8ce94
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.766 | 0.628 | 0.864 | wilson | |
| Risk in group 2 | 0.564 | 0.41 | 0.707 | wilson | |
| Risk difference, group 1 minus group 2 | 0.202 | 0.0031 | 0.385 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.36 | 0.988 | 1.87 | log | |
| Odds ratio, group 1 over group 2 | 2.53 | 1 | 6.38 | log | |
| Number needed to treat, for one more participant with the outcome on cBSI/R-IE - CF-301 than on cBSI/R-IE - Placebo | 4.95 | 2.6 | 323 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | cBSI/R-IE - CF-301 | Patients with cBSI/R-IE that received CF-301 | 36 | 47 | OG000 |
| Group 2 | cBSI/R-IE - Placebo | Patients with cBSI/R-IE that received Placebo | 22 | 39 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- POST_HOC
- Title
- Clinical Responders at Day 14 in Patients With cBSI/R-IE
- Description
Description of clinical responder at Day 14 in patients with complicated bloodstream infection (cBSI) / right-sided endocarditis (R-IE) (excluding left-sided endocarditis) in the mITT population. Responder (clinical outcome of improvement or response) was defined as survival with improvement or resolution of attributable signs and symptoms, and without new signs or symptoms, new foci of infection, change in antibiotics due to non-response, complications of S. aureus, or further surgery or medical intervention to treat S. aureus.
- Time frame
- Day 14
- Population
- mITT population
Source ClinicalTrials.gov
Trial
- Title
- Safety, Efficacy and Pharmacokinetics of CF-301 vs. Placebo in Addition to Antibacterial Therapy for Treatment of S. Aureus Bacteremia
- NCT number
- NCT03163446
- Phases
- PHASE2
- Conditions
- Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Endocarditis
- Interventions
- CF-301, Placebo
- Lead sponsor
- ContraFect
- Results first posted
- 2021-10-08
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03163446?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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