Comparison · NCT03163446-deaths
CF-301 vs Placebo: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. CF-301 vs Placebo: deaths from any cause. Trial comparisons, record NCT03163446-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03163446-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.233 | 0.151 | 0.342 | wilson | |
| Risk in group 2 | 0.188 | 0.102 | 0.319 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0454 | -0.11 | 0.184 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.24 | 0.604 | 2.55 | log | |
| Odds ratio, group 1 over group 2 | 1.32 | 0.532 | 3.25 | log | |
| Number needed to harm, for one more death from any cause on CF-301 than on Placebo | 22 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | CF-301 | Patients received a single IV infusion of CF-301 in addition to standard of care (SOC) antibacterial therapy selected by the investigator. | 17 | 73 | EG000 |
| Group 2 | Placebo | Patients received a single IV infusion of placebo in addition to standard of care (SOC) antibacterial therapy selected by the investigator. | 9 | 48 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
All AEs and SAEs were collected during the core study, from the time of consent through Test of Cure (TOC) between 56-70 days. After completion of the core study, all SAEs were collected during the long-term follow-up through Day 180.
Source ClinicalTrials.gov
Trial
- Title
- Safety, Efficacy and Pharmacokinetics of CF-301 vs. Placebo in Addition to Antibacterial Therapy for Treatment of S. Aureus Bacteremia
- NCT number
- NCT03163446
- Phases
- PHASE2
- Conditions
- Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Endocarditis
- Interventions
- CF-301, Placebo
- Lead sponsor
- ContraFect
- Results first posted
- 2021-10-08
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03163446?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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