Comparison · NCT03163446-sae
CF-301 vs Placebo: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. CF-301 vs Placebo: serious adverse events. Trial comparisons, record NCT03163446-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03163446-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.625 | 0.51 | 0.728 | wilson | |
| Risk in group 2 | 0.596 | 0.453 | 0.724 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0293 | -0.143 | 0.205 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.05 | 0.781 | 1.41 | log | |
| Odds ratio, group 1 over group 2 | 1.13 | 0.533 | 2.4 | log | |
| Number needed to harm, for one more participant with a serious adverse event on CF-301 than on Placebo | 34.2 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | CF-301 | Patients received a single IV infusion of CF-301 in addition to standard of care (SOC) antibacterial therapy selected by the investigator. | 45 | 72 | EG000 |
| Group 2 | Placebo | Patients received a single IV infusion of placebo in addition to standard of care (SOC) antibacterial therapy selected by the investigator. | 28 | 47 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
All AEs and SAEs were collected during the core study, from the time of consent through Test of Cure (TOC) between 56-70 days. After completion of the core study, all SAEs were collected during the long-term follow-up through Day 180.
Source ClinicalTrials.gov
Trial
- Title
- Safety, Efficacy and Pharmacokinetics of CF-301 vs. Placebo in Addition to Antibacterial Therapy for Treatment of S. Aureus Bacteremia
- NCT number
- NCT03163446
- Phases
- PHASE2
- Conditions
- Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Endocarditis
- Interventions
- CF-301, Placebo
- Lead sponsor
- ContraFect
- Results first posted
- 2021-10-08
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03163446?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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