Comparison · NCT03176693-b1d613eb
Phenoxybenzamine vs Doxazosin: Participants Admitted to Post-operative Intensive Care Unit (ICU)
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Phenoxybenzamine vs Doxazosin: Participants Admitted to Post-operative Intensive Care Unit (ICU). Trial comparisons, record NCT03176693-b1d613eb. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03176693-b1d613eb
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.105 | 0.0294 | 0.314 | wilson | |
| Risk in group 2 | 0.05 | 0.00888 | 0.236 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0553 | -0.146 | 0.268 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 2.11 | 0.208 | 21.4 | log | |
| Odds ratio, group 1 over group 2 | 2.24 | 0.186 | 26.9 | log | |
| Number needed to treat, for one more participant with the outcome on Phenoxybenzamine than on Doxazosin | 18.1 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Phenoxybenzamine | 3-4 weeks prior to date of surgery, patient will start phenoxybenzamine 10mg PO twice daily. Phenoxybenzamine will then be titrated to a blood pressure \<120/80 (sitting) with mild orthostatic hypotension (drop in systolic blood pressure by 20 points or diastolic blood pressure by 10 points from sitting to standing position); systolic blood pressure not less than 90 (standing).~Phenoxybenzamine: Non-selective alpha blocker | 2 | 19 | OG000 |
| Group 2 | Doxazosin | 3-4 weeks prior to date of surgery, patient will start doxazosin 1 mg PO daily. Phenoxybenzamine will then be titrated to a blood pressure \<120/80 (sitting) with mild orthostatic hypotension (drop in systolic blood pressure by 20 points or diastolic blood pressure by 10 points from sitting to standing position); systolic blood pressure not less than 90 (standing).~Doxazosin: Selective alpha blocker | 1 | 20 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Participants Admitted to Post-operative Intensive Care Unit (ICU)
- Description
- Time frame
- up to 30 days post-surgery
- Population
Source ClinicalTrials.gov
Trial
- Title
- Preoperative Alpha Blockade for Pheochromocytoma
- NCT number
- NCT03176693
- Phases
- PHASE3
- Conditions
- Pheochromocytoma, Paraganglioma
- Interventions
- Phenoxybenzamine, Doxazosin
- Lead sponsor
- University of California, Los Angeles
- Results first posted
- 2023-11-20
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03176693?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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