Comparison · NCT03229538-8b80392f
Methylprednisolone Arm vs Placebo Arm: Number of Participants With Occurrence of Any One or More of the Following STS-CHSD-defined Major Post-operative Infectious Complications: Postprocedural Infective Endocarditis, Pneumonia, Sepsis, Deep Wound Infection, Mediastinitis.
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Methylprednisolone Arm vs Placebo Arm: Number of Participants With Occurrence of Any One or More of the Following STS-CHSD-defined Major Post-operative Infectious Complications: Postprocedural Infective Endocarditis, Pneumonia, Sepsis, Deep Wound Infection, Mediastinitis. Trial comparisons, record NCT03229538-8b80392f. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03229538-8b80392f
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0518 | 0.0367 | 0.0725 | wilson | |
| Risk in group 2 | 0.0399 | 0.027 | 0.0587 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0118 | -0.0123 | 0.0363 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.3 | 0.77 | 2.18 | log | |
| Odds ratio, group 1 over group 2 | 1.31 | 0.761 | 2.26 | log | |
| Number needed to treat, for one more participant with the outcome on Methylprednisolone Arm than on Placebo Arm | 84.6 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Methylprednisolone Arm | IV Methylprednisolone~Methylprednisolone: IV Steroid pre-operative and intra-operative | 31 | 599 | OG000 |
| Group 2 | Placebo Arm | IV Isotonic Saline~Isotonic saline: Isotonic saline pre-operative and intra-operative | 24 | 601 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
Number of Participants With Occurrence of Any One or More of the Following STS-CHSD-defined Major Post-operative Infectious Complications: Postprocedural Infective Endocarditis, Pneumonia, Sepsis, Deep Wound Infection, Mediastinitis.
- Description
- Time frame
- Until hospital discharge, up to 4 months
- Population
Source ClinicalTrials.gov
Trial
- Title
- STeroids to REduce Systemic Inflammation After Infant Heart Surgery
- NCT number
- NCT03229538
- Phases
- PHASE3
- Conditions
- Congenital Heart Disease in Children, Inflammatory Response
- Interventions
- Methylprednisolone, Isotonic saline
- Lead sponsor
- Kevin Hill
- Results first posted
- 2023-05-10
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03229538?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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