Comparison · NCT03229941-76f8397d
Restrictive vs Liberal: A Composite Endpoint of All-cause Post-randomization Mortality, Myocardial Infarction (MI), Coronary Revascularization, Acute Renal Failure, or Post-randomization Ischemic Stroke up to 90 Days After Randomization
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Restrictive vs Liberal: A Composite Endpoint of All-cause Post-randomization Mortality, Myocardial Infarction (MI), Coronary Revascularization, Acute Renal Failure, or Post-randomization Ischemic Stroke up to 90 Days After Randomization. Trial comparisons, record NCT03229941-76f8397d. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03229941-76f8397d
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.101 | 0.0812 | 0.126 | wilson | |
| Risk in group 2 | 0.091 | 0.0715 | 0.115 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0104 | -0.0211 | 0.0418 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.11 | 0.805 | 1.54 | log | |
| Odds ratio, group 1 over group 2 | 1.13 | 0.786 | 1.62 | log | |
| Number needed to treat, for one more participant with the outcome on Restrictive than on Liberal | 96.3 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Restrictive | Blood transfusion trigger: Hb\<7gm/dl | 71 | 700 | OG000 |
| Group 2 | Liberal | Blood transfusion trigger: Hb\<10gm/dl | 61 | 670 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
A Composite Endpoint of All-cause Post-randomization Mortality, Myocardial Infarction (MI), Coronary Revascularization, Acute Renal Failure, or Post-randomization Ischemic Stroke up to 90 Days After Randomization
- Description
MI will be defined using the Third Universal Definition of Myocardial Infarction. Acute renal failure will be defined as Acute Kidney Injury stage III according to RIFLE criteria. Baseline creatinine will be considered the creatinine upon admission prior to the index operation. The above urine output criteria will be only used for patients who are in the ICU and have precise monitoring of their urinary output. For patients on the surgical floor only serum creatinine changes will be used for assessment of this endpoint. Coronary revascularization will be defined as a coronary artery bypass graft, or percutaneous coronary intervention (either angioplasty or stenting). Stroke will be defined as new unilateral neurological deficit that lasts for more than 24 hours, and is confirmed by a brain imaging modality (computed tomography or magnetic resonance imaging study) demonstrating new brain infarct.
- Time frame
- 90 days after randomization
- Population
- Intent to treat population
Source ClinicalTrials.gov
Trial
- Title
- Transfusion Trigger After Operations in High Cardiac Risk Patients
- NCT number
- NCT03229941
- Phases
- NA
- Conditions
- Myocardial Infarction, Coronary Revascularization, Acute Renal Failure
- Interventions
- Blood Transfusion
- Lead sponsor
- VA Office of Research and Development
- Results first posted
- 2025-09-05
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03229941?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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