Comparison · NCT03229941-c2cd4fe6
Restrictive vs Liberal: A Composite Endpoint of Cardiac Complications (Other Than MI) at 90 Days Post-randomization: Cardiac Complications Include New Cardiac Arrhythmias That Necessitate New Treatment, New or Worsening Congestive Heart Failure, and Non Fatal Cardiac Arrest
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Restrictive vs Liberal: A Composite Endpoint of Cardiac Complications (Other Than MI) at 90 Days Post-randomization: Cardiac Complications Include New Cardiac Arrhythmias That Necessitate New Treatment, New or Worsening Congestive Heart Failure, and Non Fatal Cardiac Arrest. Trial comparisons, record NCT03229941-c2cd4fe6. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03229941-c2cd4fe6
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0988 | 0.0786 | 0.124 | wilson | |
| Risk in group 2 | 0.0587 | 0.0431 | 0.0796 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0401 | 0.011 | 0.0694 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.68 | 1.15 | 2.47 | log | |
| Odds ratio, group 1 over group 2 | 1.76 | 1.16 | 2.66 | log | |
| Number needed to treat, for one more participant with the outcome on Restrictive than on Liberal | 24.9 | 14.4 | 90.8 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Restrictive | Blood transfusion trigger: Hb\<7gm/dl | 67 | 678 | OG000 |
| Group 2 | Liberal | Blood transfusion trigger: Hb\<10gm/dl | 38 | 647 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
A Composite Endpoint of Cardiac Complications (Other Than MI) at 90 Days Post-randomization: Cardiac Complications Include New Cardiac Arrhythmias That Necessitate New Treatment, New or Worsening Congestive Heart Failure, and Non Fatal Cardiac Arrest
- Description
The diagnosis of cardiac arrhythmias will be based on EKG findings. Only arrhythmias that result in initiation of new treatment regimen (to include medications, implantable devices, or surgical intervention) during hospitalization will be recorded.~CHF will require at least one of the following symptoms or signs new or worsening: dyspnea at rest, orthopnea, or paroxysmal nocturnal dyspnea and radiological evidence of heart failure or worsening heart failure and increase/initiation of established treatment.~Cardiac arrest will be defined as the cessation of cardiac pump function activity that results in loss of consciousness and absence of circulating blood flow as evidenced by absent carotid pulse. Only episodes of cardiac arrest that are reversed will be collected under this endpoint. If they are not reversed the event will be categorized as death.
- Time frame
- 90 days after randomization
- Population
- Intent to treat population
Source ClinicalTrials.gov
Trial
- Title
- Transfusion Trigger After Operations in High Cardiac Risk Patients
- NCT number
- NCT03229941
- Phases
- NA
- Conditions
- Myocardial Infarction, Coronary Revascularization, Acute Renal Failure
- Interventions
- Blood Transfusion
- Lead sponsor
- VA Office of Research and Development
- Results first posted
- 2025-09-05
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03229941?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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