Comparison · NCT03271021-a7bfef96
FMX101, 4% Minocycline Foam vs Vehicle Foam: IGA Treatment Success (Dichotomized as Yes/no) at Week 9, Where Success is Defined as an IGA Score of 0 or 1, and at Least a 2-grade Improvement (Decrease) From Baseline at the Interim Visit at Week 9
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. FMX101, 4% Minocycline Foam vs Vehicle Foam: IGA Treatment Success (Dichotomized as Yes/no) at Week 9, Where Success is Defined as an IGA Score of 0 or 1, and at Least a 2-grade Improvement (Decrease) From Baseline at the Interim Visit at Week 9. Trial comparisons, record NCT03271021-a7bfef96. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03271021-a7bfef96
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.186 | 0.159 | 0.215 | wilson | |
| Risk in group 2 | 0.105 | 0.0853 | 0.129 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0803 | 0.0446 | 0.116 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.76 | 1.36 | 2.28 | log | |
| Odds ratio, group 1 over group 2 | 1.94 | 1.44 | 2.61 | log | |
| Number needed to treat, for one more participant with the outcome on FMX101, 4% Minocycline Foam than on Vehicle Foam | 12.5 | 8.62 | 22.4 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: vehicle.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | FMX101, 4% Minocycline Foam | FMX101, 4% minocycline foam applied topically once daily for 12 weeks~FMX101: FMX101, 4% minocycline foam | 137 | 738 | OG000 |
| Group 2 | Vehicle Foam | Vehicle foam applied topically once daily for 12 weeks~Vehicle Foam: Vehicle Foam | 79 | 750 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- IGA Treatment Success (Dichotomized as Yes/no) at Week 9, Where Success is Defined as an IGA Score of 0 or 1, and at Least a 2-grade Improvement (Decrease) From Baseline at the Interim Visit at Week 9
- Description
- Time frame
- 9 weeks
- Population
Source ClinicalTrials.gov
Trial
- Title
- A Study to Evaluate the Efficacy and Safety of Topical Administration of FMX101 in the Treatment of Moderate-to-Severe Acne Vulgaris
- NCT number
- NCT03271021
- Phases
- PHASE3
- Conditions
- Acne Vulgaris
- Interventions
- FMX101, Vehicle Foam
- Lead sponsor
- Vyne Therapeutics Inc.
- Results first posted
- 2020-02-21
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03271021?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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