Comparison · NCT03278886-14344289
Low Dose Naltrexone vs Nalmefene: Number of Participants With Adherence Assessed Via Riboflavin in the Urine Confirming Adherence
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Low Dose Naltrexone vs Nalmefene: Number of Participants With Adherence Assessed Via Riboflavin in the Urine Confirming Adherence. Trial comparisons, record NCT03278886-14344289. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03278886-14344289
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.125 | 0.0224 | 0.471 | wilson | |
| Risk in group 2 | 0 | 0 | 0.658 | wilson | |
| Risk difference, group 1 minus group 2 | 0.125 | -0.541 | 0.471 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | log | a group has no participants with the outcome | |||
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat, for one more participant with the outcome on Low Dose Naltrexone than on Nalmefene | 8 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Low Dose Naltrexone | Participants randomized to this group will receive low dose naltrexone (4.5 mg) for 8 weeks.~Low dose naltrexone: 4.5 mg of low dose naltrexone taken once daily for 8 weeks | 1 | 8 | OG000 |
| Group 2 | Nalmefene | Participants randomized to this group will receive nalmefene (18 mg) for 8 weeks.~Nalmefene: 18 mg of nalmefene taken once daily for 8 weeks | 0 | 2 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Adherence Assessed Via Riboflavin in the Urine Confirming Adherence
- Description
- Measured through visual inspection of the urine for the presence or absence of riboflavin using ultraviolet (UV) light at the long wave setting (33 mm) in a room with low ambient light.
- Time frame
- Endpoint at 8 weeks
- Population
Source ClinicalTrials.gov
Trial
- Title
- St. PETERsburg Pain and Alcohol Intervention With Naltrexone and Nalmefene
- NCT number
- NCT03278886
- Phases
- PHASE1, PHASE2
- Conditions
- HIV Infection, Alcohol Use, Pain
- Interventions
- Low dose naltrexone, Nalmefene
- Lead sponsor
- Boston Medical Center
- Results first posted
- 2020-08-03
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03278886?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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