Comparison · NCT03282981-c5620c62
Timolol vs SOC Plus Non Biologically Active Gel: Percentage of Complete Wound Closure, as Assessed Over a 12 Week Period
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Timolol vs SOC Plus Non Biologically Active Gel: Percentage of Complete Wound Closure, as Assessed Over a 12 Week Period. Trial comparisons, record NCT03282981-c5620c62. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03282981-c5620c62
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.381 | 0.208 | 0.591 | wilson | |
| Risk in group 2 | 0.259 | 0.132 | 0.447 | wilson | |
| Risk difference, group 1 minus group 2 | 0.122 | -0.134 | 0.368 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.47 | 0.635 | 3.4 | log | |
| Odds ratio, group 1 over group 2 | 1.76 | 0.513 | 6.02 | log | |
| Number needed to treat, for one more participant with the outcome on Timolol than on SOC Plus Non Biologically Active Gel | 8.22 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Timolol | Timoptic-XE plus standard of care (SOC)~Timolol: Topical application of Timolol on non-healing diabetic foot ulcers | 8 | 21 | OG000 |
| Group 2 | SOC Plus Non Biologically Active Gel | SOC plus non biologically active gel (hydrogel as placebo medication)~Non biologically active gel: Topical application of non biologically active gel (Hydrogel- standard of care) on non-healing diabetic foot ulcers | 7 | 27 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Percentage of Complete Wound Closure, as Assessed Over a 12 Week Period
- Description
Complete wound closure will be assessed by Investigators and is defined as 100% epithelialization of the wound site (skin re-epithelialization without drainage or dressing requirements by Week 12). The primary outcome was the proportion of patients with complete wound healing by the end of the treatment phase, evaluated using Fisher's exact test.
- Time frame
- 12 weeks
- Population
- chronic, diabetic foot ulcerations
Source ClinicalTrials.gov
Trial
- Title
- Beta Adrenergic Antagonist for the Healing of Chronic DFU
- NCT number
- NCT03282981
- Phases
- PHASE3
- Conditions
- Chronic Diabetic Foot Ulcers, Diabetic Neuropathic Ulcers, Non Healing Wound
- Interventions
- Timolol, Non biologically active gel
- Lead sponsor
- VA Office of Research and Development
- Results first posted
- 2025-04-25
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03282981?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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