Comparison · NCT03296813-a084e1c1
Torsemide vs Furosemide: All-cause Mortality, as Measured by Follow-up Phone Call or NDI
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Torsemide vs Furosemide: All-cause Mortality, as Measured by Follow-up Phone Call or NDI. Trial comparisons, record NCT03296813-a084e1c1. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03296813-a084e1c1
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.261 | 0.239 | 0.284 | wilson | |
| Risk in group 2 | 0.262 | 0.24 | 0.285 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00125 | -0.0334 | 0.0309 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.995 | 0.88 | 1.13 | log | |
| Odds ratio, group 1 over group 2 | 0.994 | 0.841 | 1.17 | log | |
| Number needed to treat, for one fewer participant with the outcome on Torsemide than on Furosemide | 801 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Torsemide | Oral dosing of torsemide compared to furosemide will be 1mg:2-4mg.~Torsemide: Loop diuretic | 373 | 1,431 | OG000 |
| Group 2 | Furosemide | Oral dosing of torsemide compared to furosemide will be 1mg:2-4mg.~For patients receiving loop diuretics other than furosemide, conversion to furosemide equivalents will be as follows:~1 mg oral torsemide = 2-4 mg oral furosemide~1 mg oral or intravenous bumetanide = 40 mg oral furosemide~Furosemide: Loop diuretic | 374 | 1,428 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- All-cause Mortality, as Measured by Follow-up Phone Call or NDI
- Description
Death information was obtained from the Call Center through 30 months for patients 1-500, through 24 months for patients 501-1000, through 18 months for patients 1001-1500, and through 12 months for the remaining patients (except those who were randomized \< 12 months when the study was stopped by the DSMB). Also death information was obtained through searches of the 2018-2021 National Death Index (NDI) database.
- Time frame
- up to 30 months
- Population
Source ClinicalTrials.gov
Trial
- Title
- TRANSFORM-HF: ToRsemide compArisoN With furoSemide FORManagement of Heart Failure
- NCT number
- NCT03296813
- Phases
- PHASE3
- Conditions
- Heart Failure
- Interventions
- Torsemide, Furosemide
- Lead sponsor
- Duke University
- Results first posted
- 2025-10-16
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03296813?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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