Comparison · NCT03303521-sae
Sodium Zirconium Cyclosilicate (SZC) vs Placebo: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Sodium Zirconium Cyclosilicate (SZC) vs Placebo: serious adverse events. Trial comparisons, record NCT03303521-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03303521-sae
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0729 | 0.0358 | 0.143 | wilson | |
| Risk in group 2 | 0.0808 | 0.0415 | 0.151 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00789 | -0.0877 | 0.0724 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.902 | 0.34 | 2.39 | log | |
| Odds ratio, group 1 over group 2 | 0.895 | 0.311 | 2.57 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Sodium Zirconium Cyclosilicate (SZC) than on Placebo | 127 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Sodium Zirconium Cyclosilicate (SZC) | Suspension administered orally for a treatment period of eight weeks (4 weeks of dose adjustment, 4 weeks in stable dose).~Single dose contains 1 to 3 sachets that should be suspended in 45 mL of water by patient and administered on non-dialysis days. | 7 | 96 | EG000 |
| Group 2 | Placebo | Suspension administered orally for a treatment period of eight weeks (4 weeks of dose adjustment, 4 weeks in stable dose).~Single dose contains 1 to 3 sachets that should be suspended in 45 mL of water by patient and administered on non-dialysis days. | 8 | 99 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
Adverse Events will be collected from time of randomization throughout the treatment period and including the follow-up period (until Visit 16 or the last patient visit in the study), up to 10 weeks (Day 71 +/- 3 days). SAEs will be recorded from the time of informed consent.
Source ClinicalTrials.gov
Trial
- Title
- A Study to Test Whether ZS (Sodium Zirconium Cyclosilicate) Can Reduce the Incidence of Increased Blood Potassium Levels Among Dialized Patients.
- NCT number
- NCT03303521
- Phases
- PHASE3
- Conditions
- Hyperkalemia
- Interventions
- Placebo, Sodium Zirconium Cyclosilicate (ZS)
- Lead sponsor
- AstraZeneca
- Results first posted
- 2020-02-20
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03303521?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
The record is JSON. No key.
GET https://conductscience.org/api/comparisons/v1/NCT03303521-sae