Comparison · NCT03338569-27fa973c
Intervention vs Placebo: Number of Participants With Need for Renal Replacement Therapy
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Intervention vs Placebo: Number of Participants With Need for Renal Replacement Therapy. Trial comparisons, record NCT03338569-27fa973c. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03338569-27fa973c
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.164 | 0.0916 | 0.276 | wilson | |
| Risk in group 2 | 0.0313 | 0.00861 | 0.107 | wilson | |
| Risk difference, group 1 minus group 2 | 0.133 | 0.0279 | 0.247 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 5.25 | 1.2 | 23 | log | |
| Odds ratio, group 1 over group 2 | 6.08 | 1.27 | 29 | log | |
| Number needed to treat, for one more participant with the outcome on Intervention than on Placebo | 7.54 | 4.05 | 35.8 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Intervention | Vitamin C~Vitamin C: Continuous infusion of vitamin C | 10 | 61 | OG001 |
| Group 2 | Placebo | Placebo designed to mimic intervention~Placebo: Placebo designed to mimic intervention | 2 | 64 | OG000 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Need for Renal Replacement Therapy
- Description
- Outcome is reported as the number of participants who require renal replacement therapy
- Time frame
- 4 days
- Population
Source ClinicalTrials.gov
Trial
- Title
- Vitamin C and Septic Shock
- NCT number
- NCT03338569
- Phases
- PHASE2, PHASE3
- Conditions
- Septic Shock, Sepsis
- Interventions
- Vitamin C, Placebo
- Lead sponsor
- University of Minnesota
- Results first posted
- 2021-07-14
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03338569?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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