Comparison · NCT03401229-1881ede1
Benra 30 mg vs Placebo: Percentage of Subjects With NP Surgery or SCS_NP
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Benra 30 mg vs Placebo: Percentage of Subjects With NP Surgery or SCS_NP. Trial comparisons, record NCT03401229-1881ede1. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03401229-1881ede1
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.348 | 0.286 | 0.415 | wilson | |
| Risk in group 2 | 0.448 | 0.381 | 0.517 | wilson | |
| Risk difference, group 1 minus group 2 | -0.1 | -0.193 | -0.00574 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.776 | 0.61 | 0.987 | log | |
| Odds ratio, group 1 over group 2 | 0.656 | 0.441 | 0.977 | log | |
| Number needed to treat, for one fewer participant with the outcome on Benra 30 mg than on Placebo | 9.96 | 5.19 | 174 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Benra 30 mg | Benra administered every 4 weeks for the first 3 doses - Weeks 0, 4 and 8 and every 8 weeks thereafter - Weeks 16, 24, 32, 40 and 48. | 72 | 207 | OG000 |
| Group 2 | Placebo | Placebo administered every 4 weeks for the first 3 doses - Weeks 0, 4 and 8 and every 8 weeks thereafter - Weeks 16, 24, 32, 40 and 48. | 91 | 203 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Percentage of Subjects With NP Surgery or SCS_NP
- Description
The percentage of patients who had nasal polyposis (NP) surgery or systemic corticosteroids use for nasal polyposis (SCS\_NP) surgery up to week 56 was summarized and analyzed using the Cochran-Mantel-Haenszel test stratified by region (US vs non-US) and baseline comorbid asthma status (yes vs no).
- Time frame
- Baseline to week 56
- Population
Full analysis set: All patients randomized and receiving any IP are included in the full analysis set (FAS), irrespective of their protocol adherence and continued participation in the study. Patients are analyzed according to their randomized treatment.
Source ClinicalTrials.gov
Trial
- Title
- Efficacy and Safety Study of Benralizumab for Patients With Severe Nasal Polyposis
- NCT number
- NCT03401229
- Phases
- PHASE3
- Conditions
- Nasal Polyposis
- Interventions
- Benralizumab 30 mg SC + Mometasone Furoate, Matching placebo SC + Mometasone Furoate
- Lead sponsor
- AstraZeneca
- Results first posted
- 2021-10-12
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03401229?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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