Comparison · NCT03436732-deaths
140 mcg/kg LMB-100 + SEL-110 vs 100 mcg/kg LMB-100 + SEL-110: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. 140 mcg/kg LMB-100 + SEL-110 vs 100 mcg/kg LMB-100 + SEL-110: deaths from any cause. Trial comparisons, record NCT03436732-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03436732-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.5 | 0.15 | 0.85 | wilson | |
| Risk in group 2 | 1 | 0.207 | 1 | wilson | |
| Risk difference, group 1 minus group 2 | -0.5 | -0.85 | 0.367 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.5 | 0.188 | 1.33 | log | |
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat, for one fewer death from any cause on 140 mcg/kg LMB-100 + SEL-110 than on 100 mcg/kg LMB-100 + SEL-110 | 2 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | 140 mcg/kg LMB-100 + SEL-110 | Dose escalation - patients with mesothelioma treated with LMB-100+SEL-110 at escalating doses~LMB-100: administered on days 1, 3 and 5 of each 21 day cycle for up to 4 cycles~SEL-110: administered on day 1 of each cycle for up to 4 cycles | 2 | 4 | EG000 |
| Group 2 | 100 mcg/kg LMB-100 + SEL-110 | Dose escalation - patients with mesothelioma treated with LMB-100+SEL-110 at escalating doses~LMB-100: administered on days 1, 3 and 5 of each 21 day cycle for up to 4 cycles~SEL-110: administered on day 1 of each cycle for up to 4 cycles | 1 | 1 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
- Date treatment consent signed to date off study, approximately one month and 25 days for the 100 mcg/kg Arm/Group, and 9 months and 28 days for the 140 mcg/kg Arm/Group.
Source ClinicalTrials.gov
Trial
- Title
- Mesothelin-Targeted Immunotoxin LMB-100 in Combination With SEL-110 in Subjects With Malignant Pleural or Peritoneal Mesothelioma
- NCT number
- NCT03436732
- Phases
- PHASE1
- Conditions
- Mesothelioma
- Interventions
- LMB-100, SEL-110
- Lead sponsor
- National Cancer Institute (NCI)
- Results first posted
- 2019-11-22
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03436732?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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