Comparison · NCT03465722-deaths
Avapritinib vs Regorafinib: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Avapritinib vs Regorafinib: deaths from any cause. Trial comparisons, record NCT03465722-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03465722-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.372 | 0.314 | 0.435 | wilson | |
| Risk in group 2 | 0.372 | 0.312 | 0.435 | wilson | |
| Risk difference, group 1 minus group 2 | 0.00059 | -0.086 | 0.0871 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1 | 0.792 | 1.27 | log | |
| Odds ratio, group 1 over group 2 | 1 | 0.69 | 1.46 | log | |
| Number needed to harm, for one more death from any cause on Avapritinib than on Regorafinib | 1,690 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Avapritinib | 300 mg PO QD avapritinib: Avapritinib tablets for oral administration. Avapritinib will be dosed at 300 mg once daily, continuously. | 89 | 239 | EG000 |
| Group 2 | Regorafinib | 160 mg PO QD regorafenib: Regorafenib tablets for oral administration. Regorafenib will be dosed at 160 mg once daily for 3 weeks out of every 4 weeks (ie. 3 weeks on/1 week off). | 87 | 234 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
- From the date of first study drug administration to 30 days after last study drug administration, approximately 6 months
Source ClinicalTrials.gov
Trial
- Title
- (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST
- NCT number
- NCT03465722
- Phases
- PHASE3
- Conditions
- GIST
- Interventions
- avapritinib, regorafenib
- Lead sponsor
- Blueprint Medicines Corporation
- Results first posted
- 2021-05-14
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03465722?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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