Comparison · NCT03550794-4e5b30cd
Thiamine vs Placebo: Number of Participants Experiences Acute Renal Failure
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Thiamine vs Placebo: Number of Participants Experiences Acute Renal Failure. Trial comparisons, record NCT03550794-4e5b30cd. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03550794-4e5b30cd
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.548 | 0.399 | 0.688 | wilson | |
| Risk in group 2 | 0.739 | 0.597 | 0.844 | wilson | |
| Risk difference, group 1 minus group 2 | -0.192 | -0.373 | 0.0078 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.741 | 0.536 | 1.02 | log | |
| Odds ratio, group 1 over group 2 | 0.427 | 0.174 | 1.05 | log | |
| Number needed to treat, for one fewer participant with the outcome on Thiamine than on Placebo | 5.22 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Thiamine | 200mg parenterally administered thiamine hydrochloride given twice daily for a 3 days (6 doses)~Thiamine Hydrochloride: Thiamine hydrochloride is a water soluble vitamin (vitamin B1). 200mg of thiamine hydrochloride in 50ml 0.9%NACL will be administered twice daily for 3 days. | 23 | 42 | OG000 |
| Group 2 | Placebo | Matching placebo (50ml 0.9%NACL) given twice daily for 3 days (6 administrations)~Placebo: 50ml of 0.9% NACL will serve as the placebo | 34 | 46 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants Experiences Acute Renal Failure
- Description
Acute renal failure as defined by the KDIGO (Kidney Disease Improving Global Outcomes) AKI (Acute Kidney Injury) criteria. In brief, a patient can meet these criteria if their serum creatinine increases (for example, serum creatinine increases to 1.5x or higher of baseline serum creatinine, or if it crosses 4mg/dL), or if renal replacement therapy is initiated, or if urine output decreases (for example, \<0.5ml/kg/hour for 6-12 hours) or if patient becomes anuric (no urine production).
- Time frame
- From date of enrollment until day of discharge from the index ICU admission or date of death, whichever comes first up until 60 days post-enrollment
- Population
Source ClinicalTrials.gov
Trial
- Title
- Thiamine as a Renal Protective Agent in Septic Shock
- NCT number
- NCT03550794
- Phases
- PHASE2
- Conditions
- Sepsis, Kidney Injury, Thiamine Deficiency
- Interventions
- Thiamine Hydrochloride, Placebo
- Lead sponsor
- Beth Israel Deaconess Medical Center
- Results first posted
- 2023-06-27
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03550794?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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