Comparison · NCT03575052-325d55ea
Pimavanserin 34 mg vs Placebo: Treatment-emergent Adverse Events (TEAEs)
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Pimavanserin 34 mg vs Placebo: Treatment-emergent Adverse Events (TEAEs). Trial comparisons, record NCT03575052-325d55ea. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03575052-325d55ea
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.304 | 0.26 | 0.351 | wilson | |
| Risk in group 2 | 0.293 | 0.25 | 0.34 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0102 | -0.0537 | 0.074 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.03 | 0.835 | 1.28 | log | |
| Odds ratio, group 1 over group 2 | 1.05 | 0.773 | 1.43 | log | |
| Number needed to treat, for one more participant with the outcome on Pimavanserin 34 mg than on Placebo | 98 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Pimavanserin 34 mg | Pimavanserin 34 mg (administered as 2 x 17 mg capsules) once daily | 119 | 392 | OG001 |
| Group 2 | Placebo | Pimavanserin matching placebo (administered as 2 capsules) once daily | 115 | 392 | OG000 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Treatment-emergent Adverse Events (TEAEs)
- Description
- Number (%) of patients with treatment-emergent AEs
- Time frame
- Treatment Period: 8 weeks
- Population
- All patients randomised and treated
Source ClinicalTrials.gov
Trial
- Title
- A Safety Study of Pimavanserin in Adult and Elderly Subjects Experiencing Neuropsychiatric Symptoms Related to Neurodegenerative Disease
- NCT number
- NCT03575052
- Phases
- PHASE3
- Conditions
- Neuropsychiatric Symptoms Related to Neurodegenerative Disease
- Interventions
- Pimavanserin, Placebo
- Lead sponsor
- ACADIA Pharmaceuticals Inc.
- Results first posted
- 2024-12-31
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03575052?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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