Comparison · NCT03575052-sae
Pimavanserin 34 mg vs Placebo: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Pimavanserin 34 mg vs Placebo: serious adverse events. Trial comparisons, record NCT03575052-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03575052-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0204 | 0.0104 | 0.0397 | wilson | |
| Risk in group 2 | 0.0153 | 0.00703 | 0.033 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0051 | -0.0152 | 0.0261 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.33 | 0.467 | 3.81 | log | |
| Odds ratio, group 1 over group 2 | 1.34 | 0.461 | 3.9 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Pimavanserin 34 mg than on Placebo | 196 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Pimavanserin 34 mg | Pimavanserin 34 mg (administered as 2 x 17 mg capsules) once daily | 8 | 392 | EG001 |
| Group 2 | Placebo | Pimavanserin matching placebo (administered as 2 capsules) once daily | 6 | 392 | EG000 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Treatment period (8 weeks) and follow-up period (30 days): total of approximately 15 weeks
Source ClinicalTrials.gov
Trial
- Title
- A Safety Study of Pimavanserin in Adult and Elderly Subjects Experiencing Neuropsychiatric Symptoms Related to Neurodegenerative Disease
- NCT number
- NCT03575052
- Phases
- PHASE3
- Conditions
- Neuropsychiatric Symptoms Related to Neurodegenerative Disease
- Interventions
- Pimavanserin, Placebo
- Lead sponsor
- ACADIA Pharmaceuticals Inc.
- Results first posted
- 2024-12-31
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03575052?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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