Comparison · NCT03577730-sae
Experimental vs Control: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Experimental vs Control: serious adverse events. Trial comparisons, record NCT03577730-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03577730-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0606 | 0.0168 | 0.196 | wilson | |
| Risk in group 2 | 0.129 | 0.0513 | 0.289 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0684 | -0.234 | 0.0877 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.47 | 0.0925 | 2.39 | log | |
| Odds ratio, group 1 over group 2 | 0.435 | 0.0739 | 2.57 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Experimental than on Control | 14.6 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: control.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Experimental | Prepared intravenous piggyback solution of caffeine citrate (200 mg caffeine) will be directly delivered to the operating room prior to the surgery of enrolled participants who are randomized to this group.~Caffeine Citrate: Prepared intravenous piggyback solutions of caffeine citrate (200 mg caffeine) will be directly delivered to the operating room prior to the surgery of enrolled participants. | 2 | 33 | EG000 |
| Group 2 | Control | Prepared intravenous piggyback solution of 5 percent dextrose water will be directly delivered to the operating room prior to the surgery of enrolled participants who are randomized to this group.~Dextrose Water: Prepared intravenous piggyback solutions of 5 percent dextrose water will be directly delivered to the operating room prior to the surgery of enrolled participants. | 4 | 31 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Data were collected at 30 days.
Source ClinicalTrials.gov
Trial
- Title
- Caffeine and Neurologic Recovery Following Surgery and General Anesthesia
- NCT number
- NCT03577730
- Phases
- EARLY_PHASE1
- Conditions
- Pain, Postoperative
- Interventions
- Caffeine Citrate, Dextrose Water
- Lead sponsor
- University of Michigan
- Results first posted
- 2021-10-06
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03577730?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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