Comparison · NCT03615040-sae
Anti-ST2 vs Placebo: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Anti-ST2 vs Placebo: serious adverse events. Trial comparisons, record NCT03615040-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03615040-sae
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.286 | 0.172 | 0.436 | wilson | |
| Risk in group 2 | 0.41 | 0.271 | 0.566 | wilson | |
| Risk difference, group 1 minus group 2 | -0.125 | -0.317 | 0.0802 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.696 | 0.379 | 1.28 | log | |
| Odds ratio, group 1 over group 2 | 0.575 | 0.228 | 1.45 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Anti-ST2 than on Placebo | 8.03 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Anti-ST2 | Anti-ST2 (MSTT1041A\*) received as subcutaneous injection by infusion pump at 490mg every 4 weeks over a 48 week treatment period.~Anti-ST2 was presented as sterile, clear, and colourless to slightly yellow liquid. Each sterile vial is filled with a 1 mL deliverable volume of 70 mg/mL. It was formulated with 15 mM sodium acetate, 9.0% (w/v) sucrose, 0.01% (w/v) polysorbate 20, pH 5.2.~\*Official USAN name for MSTT1041A is now astegolimab | 12 | 42 | EG000 |
| Group 2 | Placebo | Placebo (no active component) received as subcutaneous injection by infusion pump at 490mg every 4 weeks over a 48 week treatment period.~Placebo for Anti-ST2 (MSTT1041A) was formulated with 10 mM sodium acetate, 9.0% (w/v) sucrose, 0.004% (w/v) polysorbate 20, pH 5.2, and was supplied in an identical vial configuration. | 16 | 39 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
Adverse event data occurring from the point of randomisation until the final trial visit following follow-up (or 100 days post cessation of trial treatment (if discontinued early), were recorded throughout the 48 week treatment period and 12 week post-trial follow-up.
Source ClinicalTrials.gov
Trial
- Title
- Anti-ST2 (MSTT1041A) in COPD (COPD-ST2OP)
- NCT number
- NCT03615040
- Phases
- PHASE2
- Conditions
- COPD Exacerbation
- Interventions
- MSTT1041A, Placebo
- Lead sponsor
- University of Leicester
- Results first posted
- 2022-05-24
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03615040?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
The record is JSON. No key.
GET https://conductscience.org/api/comparisons/v1/NCT03615040-sae