Comparison · NCT03640949-8babbc47
Vasopressin and Methylprednisolone vs Placebo: Number of Participants With Return of Spontaneous Circulation
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Vasopressin and Methylprednisolone vs Placebo: Number of Participants With Return of Spontaneous Circulation. Trial comparisons, record NCT03640949-8babbc47. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03640949-8babbc47
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.422 | 0.361 | 0.486 | wilson | |
| Risk in group 2 | 0.326 | 0.272 | 0.384 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0962 | 0.0114 | 0.179 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.3 | 1.03 | 1.63 | log | |
| Odds ratio, group 1 over group 2 | 1.51 | 1.05 | 2.17 | log | |
| Number needed to treat, for one more participant with the outcome on Vasopressin and Methylprednisolone than on Placebo | 10.4 | 5.57 | 87.4 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Vasopressin and Methylprednisolone | The study drugs will consist of 40 mg methylprednisolone (Solu-medrol®, Pfizer) and 20 IU of vasopressin (Empressin®, Amomed Pharma GmbH) given as soon as possible after the first dose of adrenaline. Additional doses of vasopressin (20 IU) will be administered after each adrenaline dose for a maximum of four doses (80 IU).~Vasopressin, Arginine: 20 IE of vasopressin per dose for a maximum of four doses (80 IU)~Methylprednisolone: 40 mg methylprednisolone once | 100 | 237 | OG000 |
| Group 2 | Placebo | The placebo for vasopressin will consist of 1 mL of 9 mg/mL NaCl (normal saline) from 2 mL ampules identical to the vasopressin ampules. The placebo for methylprednisolone will also consist of 1 mL of 9 mg/mL NaCl.~NaCl: Placebo | 86 | 264 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number of Participants With Return of Spontaneous Circulation
- Description
- Return of spontaneous circulation is defined as spontaneous circulation with no further need for chest compressions sustained for at least 20 minutes
- Time frame
- During the cardiac arrest, an average of 20 minutes
- Population
Source ClinicalTrials.gov
Trial
- Title
- Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest
- NCT number
- NCT03640949
- Phases
- PHASE2, PHASE3
- Conditions
- Heart Arrest
- Interventions
- Vasopressin, Arginine, Methylprednisolone, NaCl
- Lead sponsor
- Lars Wiuff Andersen
- Results first posted
- 2022-01-11
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03640949?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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