No PN Use (Project B) vs PN Use (Project B): Survival to Discharge Home (Project B)
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
Measures 6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note | Source |
|---|---|---|---|---|---|---|
| Risk in group 1 | 0.98 | 0.977 | 0.983 | wilson | ClinicalTrials.gov | |
| Risk in group 2 | 0.989 | 0.987 | 0.991 | wilson | ClinicalTrials.gov | |
| Risk difference, group 1 minus group 2 | -0.00859 | -0.0124 | -0.00485 | newcombe hybrid score | ClinicalTrials.gov | |
| Risk ratio, group 1 over group 2 | 0.991 | 0.988 | 0.995 | log | ClinicalTrials.gov | |
| Odds ratio, group 1 over group 2 | 0.555 | 0.427 | 0.721 | log | ClinicalTrials.gov | |
| Number needed to treat, for one fewer participant with the outcome on No PN Use (Project B) than on PN Use (Project B) | 116 | 80.5 | 206 | from the risk difference interval | ClinicalTrials.gov |
Groups 2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code | Source |
|---|---|---|---|---|---|---|
| Group 1 | No PN Use (Project B) | All neonates born between 30 and 33 weeks postmenstrual age in England and Wales and admitted to a NHS neonatal unit between 1st January 2012 and 31st December 2017 who did not receive any parenteral nutrition (for any duration, by any intravenous route) in the first seven postnatal days. | 7,987 | 8,146 | OG000 | ClinicalTrials.gov |
| Group 2 | PN Use (Project B) | All neonates born between 30 and 33 weeks postmenstrual age in England and Wales and admitted to a NHS neonatal unit between 1st January 2012 and 31st December 2017 who received any parenteral nutrition (for any duration, by any intravenous route) in the first seven postnatal days.~Parenteral nutrition: Parenteral nutrition is the administration of an intravenous solution containing amino acids (with or without lipids) to provide nutritional support. | 8,057 | 8,146 | OG001 | ClinicalTrials.gov |
Outcome 5
| Field | Value | Source |
|---|---|---|
| Type | PRIMARY | ClinicalTrials.gov |
| Title | Survival to Discharge Home (Project B) | ClinicalTrials.gov |
| Description | Defined as recorded alive at final neonatal unit discharge~This outcome formed part of Project B ONLY, and in keeping with the research protocol is only analysed and reported for the babies in this research arm. | ClinicalTrials.gov |
| Time frame | From birth until discharge home, assessed up to 1 year | ClinicalTrials.gov |
| Population | Analysis of propensity score matched cohorts as per the pre-specified analysis plan This outcome formed part of Project B ONLY, and in keeping with the research protocol is only analysed and reported for the babies in this research arm. | ClinicalTrials.gov |
Trial 8
| Field | Value | Source |
|---|---|---|
| Title | Outcomes Following Early Parenteral Nutrition Use in Preterm Neonates | ClinicalTrials.gov |
| NCT number | NCT03767634 | ClinicalTrials.gov |
| Phases | ClinicalTrials.gov | |
| Conditions | Neonatal Death, Prematurity | ClinicalTrials.gov |
| Interventions | Parenteral nutrition | ClinicalTrials.gov |
| Lead sponsor | Imperial College London | ClinicalTrials.gov |
| Results first posted | 2022-03-17 | ClinicalTrials.gov |
| Results on ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT03767634?tab=results | ClinicalTrials.gov |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trial-comparisons-2026-03-23-0.1.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57 | ClinicalTrials.gov |
| AACT copy | 2026-03-23 | ClinicalTrials.gov |
| Tables read | outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet | ClinicalTrials.gov |
Release trial-comparisons-2026-03-23-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.