Comparison · NCT03806452-ad0afea2
Hydroxycarbamide vs Placebo: Proportion of Patients With a Shift From Macroalbuminuria to Microalbuminuria
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Hydroxycarbamide vs Placebo: Proportion of Patients With a Shift From Macroalbuminuria to Microalbuminuria. Trial comparisons, record NCT03806452-ad0afea2. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03806452-ad0afea2
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0233 | 0.00412 | 0.121 | wilson | |
| Risk in group 2 | 0.0526 | 0.0146 | 0.173 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0294 | -0.151 | 0.0751 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.442 | 0.0417 | 4.68 | log | |
| Odds ratio, group 1 over group 2 | 0.429 | 0.0373 | 4.92 | log | |
| Number needed to treat, for one fewer participant with the outcome on Hydroxycarbamide than on Placebo | 34 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Hydroxycarbamide | Hydroxycarbamide will be supplied as 100 mg or 1000 mg film-coated tablets. The posology will be based on the patient's body weight (bw). Hydroxycarbamide will be prescribed at a dose of 15 mg/kg bw/day and will be adminitered for 6 months.~Hydroxycarbamide will be administered for 12 months for patients qualified as responders willing to continue to participate in the trial.~Hydroxycarbamide: Hydroxycarbamide tablets of 100 and 1000 mg | 1 | 43 | OG000 |
| Group 2 | Placebo | Placebo will be supplied as 100 mg or 1000 mg film-coated tablets. The posology will be based on the patient's body weight (bw). Placebo will be prescribed at a dose of 15 mg/kg bw/day and will be adminitered for 6 months.~Hydroxycarbamide will be administered for 12 months for patients qualified as responders willing to continue to participate in the trial.~Placebo Oral Tablet: Placebo tablets of 100 and 1000 mg to mimic hydroxycarbamide tablets | 2 | 38 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Proportion of Patients With a Shift From Macroalbuminuria to Microalbuminuria
- Description
- Time frame
- 6 months
- Population
Source ClinicalTrials.gov
Trial
- Title
- SIKAMIC (SIklos on Kidney Function and AlbuMInuria Clinical Trial)
- NCT number
- NCT03806452
- Phases
- PHASE2
- Conditions
- Sickle Cell Disease
- Interventions
- Hydroxycarbamide, Placebo Oral Tablet
- Lead sponsor
- Theravia
- Results first posted
- 2025-05-14
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03806452?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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