Comparison · NCT03882788-sae
Narcotic Based Anesthesia vs Volatile Anesthesia: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Narcotic Based Anesthesia vs Volatile Anesthesia: serious adverse events. Trial comparisons, record NCT03882788-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03882788-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.159 | 0.0793 | 0.294 | wilson | |
| Risk in group 2 | 0.222 | 0.125 | 0.363 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0631 | -0.225 | 0.103 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.716 | 0.299 | 1.71 | log | |
| Odds ratio, group 1 over group 2 | 0.662 | 0.227 | 1.93 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Narcotic Based Anesthesia than on Volatile Anesthesia | 15.8 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Narcotic Based Anesthesia | Participants receive fentanyl 5 mcg/kg/hr not to exceed 10 mcg/kg/hr (high dose). | 7 | 44 | EG000 |
| Group 2 | Volatile Anesthesia | Participants receive volatile anesthetic isoflurane (1.5-2.0%) as primary anesthetic; participants also receive rocuronium or pancuronium for muscle relaxation, and fentanyl at no greater than 2 mcg/kg/hr (low dose). | 10 | 45 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- 48 months
Source ClinicalTrials.gov
Trial
- Title
- The Effect of Anesthesia on Neurodevelopmental Outcome (NDO)
- NCT number
- NCT03882788
- Phases
- NA
- Conditions
- Anesthesia; Adverse Effect, Congenital Heart Disease, Neurodevelopmental Disorders
- Interventions
- Isoflurane, Fentanyl (high dose), Fentanyl (low dose)
- Lead sponsor
- Stanford University
- Results first posted
- 2022-05-09
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03882788?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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