Comparison · NCT03952650-2d64605f
1a - Pilot/Safety: Dosing Interval on Days: 1 vs 2a - Pilot/Safety: Dosing Interval on Days: 1: Number of Participants With Positive Sensitive Blood Smear (sBS)
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. 1a - Pilot/Safety: Dosing Interval on Days: 1 vs 2a - Pilot/Safety: Dosing Interval on Days: 1: Number of Participants With Positive Sensitive Blood Smear (sBS). Trial comparisons, record NCT03952650-2d64605f. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03952650-2d64605f
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0 | 0 | 0.49 | wilson | |
| Risk in group 2 | 0 | 0 | 0.49 | wilson | |
| Risk difference, group 1 minus group 2 | 0 | -0.49 | 0.49 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | log | a group has no participants with the outcome | |||
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat | from the risk difference interval | the two groups' risks are equal |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | 1a - Pilot/Safety: Dosing Interval on Days: 1 | Participants received 1 dose of 4x10\^5 PfSPZ via direct venus inoculation (DVI) with 75 mg PYR day 0 post PfSPZ | 0 | 4 | OG000 |
| Group 2 | 2a - Pilot/Safety: Dosing Interval on Days: 1 | Participants received 1 dose of 4x10\^5 PfSPZ via direct venus inoculation (DVI) with 75 mg PYR day 2 \& 3 post PfSPZ | 0 | 4 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number of Participants With Positive Sensitive Blood Smear (sBS)
- Description
Count of participants with positive sensitive blood smear (sBS) occurring after PfSPZ-CVac immunization starting on day 7 post DVI. Only pilot phase arms (Arms 1a, 2a) were analyzed for this outcome measure. Arms 5a and 6a were not performed, as no patent parasitemia was observed in either Arms 1a or 2a, per the protocol.
- Time frame
- 7 -12 days post-inoculation
- Population
Source ClinicalTrials.gov
Trial
- Title
Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falcipa...
- NCT number
- NCT03952650
- Phases
- PHASE1, PHASE2
- Conditions
- Malaria
- Interventions
- Chloroquine Phosphate, PfSPZ Challenge, Pyrimethamine, Coartem, ibuprofen
- Lead sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
- Results first posted
- 2022-07-12
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03952650?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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GET https://conductscience.org/api/comparisons/v1/NCT03952650-2d64605f