Comparison · NCT03984188-deaths
Low-dose Theophylline Group vs Placebo Group: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Low-dose Theophylline Group vs Placebo Group: deaths from any cause. Trial comparisons, record NCT03984188-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03984188-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.04 | 0.011 | 0.135 | wilson | |
| Risk in group 2 | 0.0816 | 0.0322 | 0.192 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0416 | -0.156 | 0.0651 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.49 | 0.094 | 2.55 | log | |
| Odds ratio, group 1 over group 2 | 0.469 | 0.0818 | 2.69 | log | |
| Number needed to treat, for one fewer death from any cause on Low-dose Theophylline Group than on Placebo Group | 24 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Low-dose Theophylline Group | Participant in this group will receive low-dose theophylline in addition to standard care, per World Health Organization (WHO) guidelines for management of Chronic Obstructive Pulmonary Disease (COPD) treatment, over a one year period.~Theophylline ER: 200 mg extended release (ER) low-dose theophylline taken orally daily~Standard of Care Treatment: Per World Health Organization (WHO) guidelines for management of Chronic Obstructive Pulmonary Disease (COPD) treatment | 2 | 50 | EG000 |
| Group 2 | Placebo Group | Participant in this group will receive a placebo in addition to standard care, per World Health Organization (WHO) guidelines for management of Chronic Obstructive Pulmonary Disease (COPD) treatment.~Placebo oral tablet: Manufactured methylcellulose placebo tablet taken orally daily~Standard of Care Treatment: Per World Health Organization (WHO) guidelines for management of Chronic Obstructive Pulmonary Disease (COPD) treatment | 4 | 49 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
- 1 year
Source ClinicalTrials.gov
Trial
- Title
- Effectiveness of Low-Dose Theophylline for the Management of Biomass-Associated COPD
- NCT number
- NCT03984188
- Phases
- PHASE3
- Conditions
- COPD, COPD Exacerbation, COPD Exacerbation Acute, Pollution Related Respiratory Disorder, Pollution; Exposure
- Interventions
- Theophylline ER, Placebo oral tablet, Standard of Care Treatment
- Lead sponsor
- University of Miami
- Results first posted
- 2024-10-29
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03984188?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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