Comparison · NCT04095104-9d2d9bda
Phentermine & Topiramate vs Placebo: Number of Participants Adherent to Study Drugs
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Phentermine & Topiramate vs Placebo: Number of Participants Adherent to Study Drugs. Trial comparisons, record NCT04095104-9d2d9bda. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04095104-9d2d9bda
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.833 | 0.436 | 0.97 | wilson | |
| Risk in group 2 | 0 | 0.0000000000000000278 | 0.39 | wilson | |
| Risk difference, group 1 minus group 2 | 0.833 | 0.277 | 0.97 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | log | a group has no participants with the outcome | |||
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat, for one more participant with the outcome on Phentermine & Topiramate than on Placebo | 1.2 | 1.03 | 3.61 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Phentermine & Topiramate | Participants were randomized to receive phentermine and topiramate plus standard post-bariatric care. | 5 | 6 | OG000 |
| Group 2 | Placebo | Participants were randomized to receive placebo tablets compounded to look like phentermine and topiramate plus standard post-bariatric care. | 0 | 6 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number of Participants Adherent to Study Drugs
- Description
- Presence of amphetamine in the urine at any study visit
- Time frame
- 12 weeks
- Population
- The one participant randomized to the placebo group who withdrew before taking a single dose of study medication was not included in this outcome.
Source ClinicalTrials.gov
Trial
- Title
- Adjunct Phentermine + Topiramate After Bariatric Surgery in 12-24 Year Olds
- NCT number
- NCT04095104
- Phases
- PHASE2
- Conditions
- Obesity, Morbid, Bariatric Surgery, Adolescent, Young Adult, Drug Therapy
- Interventions
- Phentermine, Immediate Release Topiramate, Placebo for Phentermine, Placebo for Immediate Release Topiramate
- Lead sponsor
- University of Colorado, Denver
- Results first posted
- 2025-05-23
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04095104?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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