Comparison · NCT04134845-377e9ead
Dantrolene/Ryanodex vs Placebo: Number of Participants With Inducible Sustained Ventricular Tachycardia/ Ventricular Fibrillation (VT/VF) Utilizing Standardized Stimulation Protocol.
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Dantrolene/Ryanodex vs Placebo: Number of Participants With Inducible Sustained Ventricular Tachycardia/ Ventricular Fibrillation (VT/VF) Utilizing Standardized Stimulation Protocol. Trial comparisons, record NCT04134845-377e9ead. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04134845-377e9ead
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.138 | 0.055 | 0.306 | wilson | |
| Risk in group 2 | 0.409 | 0.233 | 0.613 | wilson | |
| Risk difference, group 1 minus group 2 | -0.271 | -0.491 | -0.0277 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.337 | 0.119 | 0.953 | log | |
| Odds ratio, group 1 over group 2 | 0.231 | 0.0596 | 0.896 | log | |
| Number needed to treat, for one fewer participant with the outcome on Dantrolene/Ryanodex than on Placebo | 3.69 | 2.04 | 36.1 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Dantrolene/Ryanodex | Dantrolene/Ryanodex; intravenous administration of dantrolene; 1 mg/ kg IV over 3 minute, one time dose~Dantrolene/Ryanodex: muscle relaxant | 4 | 29 | OG000 |
| Group 2 | Placebo | controlled placebo of saline administered Intravenous; 1 mg/kg IV over 3 minutes, one time dose~Placebo: Controlled placebo of saline administered Intravenous; 1 mg/kg IV over 3 minutes, one time dose | 9 | 22 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number of Participants With Inducible Sustained Ventricular Tachycardia/ Ventricular Fibrillation (VT/VF) Utilizing Standardized Stimulation Protocol.
- Description
Post drug ventricular stimulation with Right Ventricle (RV) ventricular catheter in the Right Ventricle( RV) apex with increasing extra stimuli with planned decrement stimuli by 10 milliseconds (ms) to effective refractory period (ERP). Outcome is measured as Ventricular inducibility yes/no.
- Time frame
- 10 minutes post drug infusion
- Population
Source ClinicalTrials.gov
Trial
- Title
- A Clinical Trial Utilizing Dantrolene in Patients With Ventricular Arrhythmias.
- NCT number
- NCT04134845
- Phases
- PHASE2, PHASE3
- Conditions
- Ventricular Tachycardia
- Interventions
- Dantrolene/Ryanodex, Placebo
- Lead sponsor
- Vanderbilt University Medical Center
- Results first posted
- 2025-08-15
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04134845?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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