Comparison · NCT04171700-sae
Rucaparib Cohort A vs Rucaparib Cohort B: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Rucaparib Cohort A vs Rucaparib Cohort B: serious adverse events. Trial comparisons, record NCT04171700-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04171700-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.206 | 0.125 | 0.322 | wilson | |
| Risk in group 2 | 0.25 | 0.112 | 0.469 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0437 | -0.277 | 0.136 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.825 | 0.335 | 2.03 | log | |
| Odds ratio, group 1 over group 2 | 0.78 | 0.239 | 2.54 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Rucaparib Cohort A than on Rucaparib Cohort B | 22.9 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Rucaparib Cohort A | Participants with a deleterious mutation in one of the following genes: BRCA1, BRCA2, PALB2, RAD51C, or RAD51D. | 13 | 63 | EG000 |
| Group 2 | Rucaparib Cohort B | Participants with a deleterious mutation in one of the following genes: BARD1, BRIP1, FANCA, NBN, RAD51, or RAD51B. | 5 | 20 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Adverse event data was collected from the date of first dose of study drug until 28 days after the last dose of study drug, approximately 2 years.
Source ClinicalTrials.gov
Trial
- Title
- A Study to Evaluate Rucaparib in Participants With Solid Tumors and With Deleterious Mutations in HRR Genes
- NCT number
- NCT04171700
- Phases
- PHASE2
- Conditions
- Solid Tumor
- Interventions
- Rucaparib
- Lead sponsor
- pharmaand GmbH
- Results first posted
- 2023-10-02
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04171700?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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