Comparison · NCT04221230-83151be4
NMRA-335140 vs Placebo: Number of Participants With Clinically Significant Changes in Vital Parameters
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. NMRA-335140 vs Placebo: Number of Participants With Clinically Significant Changes in Vital Parameters. Trial comparisons, record NCT04221230-83151be4. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04221230-83151be4
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0 | 0 | 0.0363 | wilson | |
| Risk in group 2 | 0 | 0 | 0.0363 | wilson | |
| Risk difference, group 1 minus group 2 | 0 | -0.0363 | 0.0363 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | log | a group has no participants with the outcome | |||
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat | from the risk difference interval | the two groups' risks are equal |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | NMRA-335140 | Participants were randomized in a 1:1 ratio and received 80 milligrams (mg) of NMRA-335140 once daily orally. | 0 | 102 | OG000 |
| Group 2 | Placebo | Participants were randomized in a 1:1 ratio and received matching placebo once daily orally. | 0 | 102 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Clinically Significant Changes in Vital Parameters
- Description
- The following vital parameters were analyzed: diastolic blood pressure, systolic blood pressure, temperature, heart rate and respiratory rate.
- Time frame
- Up to 8 Weeks
- Population
- Safety Population.
Source ClinicalTrials.gov
Trial
- Title
- Study in Major Depressive Disorder With NMRA-335140 (BTRX-335140) vs Placebo
- NCT number
- NCT04221230
- Phases
- PHASE2
- Conditions
- Major Depressive Disorder
- Interventions
- NMRA-335140, Placebo
- Lead sponsor
- Neumora Therapeutics, Inc.
- Results first posted
- 2025-05-29
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04221230?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
The record is JSON. No key.
GET https://conductscience.org/api/comparisons/v1/NCT04221230-83151be4