Comparison · NCT04221230-ba834005
NMRA-335140 vs Placebo: Number of Participants Reporting Suicidal Behaviors or Ideation As Assessed by Columbia-Suicide Severity Rating Scale (C-SSRS)
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. NMRA-335140 vs Placebo: Number of Participants Reporting Suicidal Behaviors or Ideation As Assessed by Columbia-Suicide Severity Rating Scale (C-SSRS). Trial comparisons, record NCT04221230-ba834005. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04221230-ba834005
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0 | 0.00000000000000000347 | 0.0487 | wilson | |
| Risk in group 2 | 0.0147 | 0.0026 | 0.0787 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0147 | -0.0787 | 0.0355 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | log | a group has no participants with the outcome | |||
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat, for one fewer participant with the outcome on NMRA-335140 than on Placebo | 68 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | NMRA-335140 | Participants were randomized in a 1:1 ratio and received 80 milligrams (mg) of NMRA-335140 once daily orally. | 0 | 75 | OG000 |
| Group 2 | Placebo | Participants were randomized in a 1:1 ratio and received matching placebo once daily orally. | 1 | 68 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants Reporting Suicidal Behaviors or Ideation As Assessed by Columbia-Suicide Severity Rating Scale (C-SSRS)
- Description
A scale to measure suicide thoughts and behavior. Suicidal thoughts are assessed by binary responses (yes/no): wish to be dead, non-specific active suicidal thoughts, active suicidal ideation with some intent to act and without specific plan, active suicidal ideation with specific plan and intent, preparatory acts or behavior, aborted attempt, interrupted attempt, actual attempt (non-fatal), and suicide death. A numerical suicidal ideation score is assigned for the first 5 binary items ranging from 0 (no ideation) to 5 (active ideation with plan and intent).
- Time frame
- At Week 8
- Population
- Safety Population who completed C-SSRS at Week 8 has been presented.
Source ClinicalTrials.gov
Trial
- Title
- Study in Major Depressive Disorder With NMRA-335140 (BTRX-335140) vs Placebo
- NCT number
- NCT04221230
- Phases
- PHASE2
- Conditions
- Major Depressive Disorder
- Interventions
- NMRA-335140, Placebo
- Lead sponsor
- Neumora Therapeutics, Inc.
- Results first posted
- 2025-05-29
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04221230?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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