Comparison · NCT04221230-d79ebb95
NMRA-335140 vs Placebo: Number of Participants With Clinically Significant Changes in Physical Examinations
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. NMRA-335140 vs Placebo: Number of Participants With Clinically Significant Changes in Physical Examinations. Trial comparisons, record NCT04221230-d79ebb95. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04221230-d79ebb95
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0 | 0 | 0.0363 | wilson | |
| Risk in group 2 | 0 | 0 | 0.0363 | wilson | |
| Risk difference, group 1 minus group 2 | 0 | -0.0363 | 0.0363 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | log | a group has no participants with the outcome | |||
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat | from the risk difference interval | the two groups' risks are equal |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | NMRA-335140 | Participants were randomized in a 1:1 ratio and received 80 milligrams (mg) of NMRA-335140 once daily orally. | 0 | 102 | OG000 |
| Group 2 | Placebo | Participants were randomized in a 1:1 ratio and received matching placebo once daily orally. | 0 | 102 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Clinically Significant Changes in Physical Examinations
- Description
Physical examination included the assessment of skin, head, ears, eyes, nose, throat, respiratory system, cardiovascular system, abdomen (including liver and kidneys), musculoskeletal system, neurological system, gastrointestinal system, genitourinary system, endocrine system and lymph nodes. Abnormality in physical examination were based on investigator's discretion.
- Time frame
- Up to 8 Weeks
- Population
- Safety Population.
Source ClinicalTrials.gov
Trial
- Title
- Study in Major Depressive Disorder With NMRA-335140 (BTRX-335140) vs Placebo
- NCT number
- NCT04221230
- Phases
- PHASE2
- Conditions
- Major Depressive Disorder
- Interventions
- NMRA-335140, Placebo
- Lead sponsor
- Neumora Therapeutics, Inc.
- Results first posted
- 2025-05-29
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04221230?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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