Comparison · NCT04333732-7d39caf8
M-M-R II ® vs Placebo: Severity of COVID-19 Measured at 60 Days After Intervention
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. M-M-R II ® vs Placebo: Severity of COVID-19 Measured at 60 Days After Intervention. Trial comparisons, record NCT04333732-7d39caf8. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04333732-7d39caf8
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.00187 | 0.000635 | 0.00547 | wilson | |
| Risk in group 2 | 0.000648 | 0.000114 | 0.00366 | wilson | |
| Risk difference, group 1 minus group 2 | 0.00122 | -0.00203 | 0.00487 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 2.88 | 0.3 | 27.7 | log | |
| Odds ratio, group 1 over group 2 | 2.89 | 0.3 | 27.8 | log | |
| Number needed to treat, for one more participant with the outcome on M-M-R II ® than on Placebo | 820 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | M-M-R II ® | Education and surveillance plus M-M-R II ® Single dose, 0.5 mL subcutaneous injection of M-M-R II ®~MR or M-M-R II ® vaccine: Education and surveillance plus MR or M-M-R II ® vaccine | 3 | 1,607 | OG000 |
| Group 2 | Placebo | Education and surveillance plus placebo Single dose, 0.5 mL subcutaneous injection of 0.9% saline~Placebo: Placebo injection | 1 | 1,544 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Severity of COVID-19 Measured at 60 Days After Intervention
- Description
Severity of COVID-19 in adults who become infected with SARS-CoV-2 by day 60 after receiving trial intervention. Severity will be graded on a simplified version of the ordinal WHO COVID-19 severity scale ((i) uninfected, (ii) infected but ambulatory \[mild disease\], (iii) infected and hospitalized \[moderate or severe disease\] or dead). Practically, this outcome measure was treated as a binary outcome - participants were classified and counted as having severe COVID-19 if they met the definition for the primary outcome of symptomatic COVID-19 AND were hospitalized during the course of their COVID-19 illness.
- Time frame
- 60 days after receiving trial intervention
- Population
Source ClinicalTrials.gov
Trial
- Title
- CROWN CORONATION: COVID-19 Research Outcomes Worldwide Network for CORONAvirus prevenTION
- NCT number
- NCT04333732
- Phases
- PHASE3
- Conditions
- COVID 19
- Interventions
- MR or M-M-R II ® vaccine, Placebo
- Lead sponsor
- Washington University School of Medicine
- Results first posted
- 2024-03-26
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04333732?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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