Comparison · NCT04344184-deaths
Infusion vs Placebo: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Infusion vs Placebo: deaths from any cause. Trial comparisons, record NCT04344184-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04344184-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.227 | 0.101 | 0.434 | wilson | |
| Risk in group 2 | 0.28 | 0.143 | 0.476 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0527 | -0.286 | 0.196 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.812 | 0.3 | 2.19 | log | |
| Odds ratio, group 1 over group 2 | 0.756 | 0.201 | 2.85 | log | |
| Number needed to treat, for one fewer death from any cause on Infusion than on Placebo | 19 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Infusion | L-Ascorbic Acid (Vitamin C), intravenous infusion~L-ascorbic acid: 50 mg/kg intravenous vitamin C infusion every 6 hours for up to 96 hours | 5 | 22 | EG000 |
| Group 2 | Placebo | Dextrose 5% Water~Placebo: Dextrose 5% Water | 7 | 25 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
- Adverse events were monitored/assessed from baseline to the end of study procedures, or until participants withdrew from the study, up to day 90 for each enrolled participant
Source ClinicalTrials.gov
Trial
- Title
- SAFEty Study of Early Infusion of Vitamin C for Treatment of Novel Coronavirus Acute Lung Injury (SAFE EVICT CORONA-ALI)
- NCT number
- NCT04344184
- Phases
- PHASE2
- Conditions
- COVID-19, Lung Injury, Acute, Kidney Injury
- Interventions
- L-ascorbic acid, Placebo
- Lead sponsor
- Virginia Commonwealth University
- Results first posted
- 2024-04-04
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04344184?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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