Comparison · NCT04344600-37697968
Peginterferon Lambda Alfa-1a vs Placebo: Number of Participants With no Evidence of SARS-CoV-2 Infection
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Peginterferon Lambda Alfa-1a vs Placebo: Number of Participants With no Evidence of SARS-CoV-2 Infection. Trial comparisons, record NCT04344600-37697968. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04344600-37697968
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 1 | 0.342 | 1 | wilson | |
| Risk in group 2 | 1 | 0.51 | 1 | wilson | |
| Risk difference, group 1 minus group 2 | 0 | -0.658 | 0.49 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1 | 1 | 1 | log | |
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat | from the risk difference interval | the two groups' risks are equal |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Peginterferon Lambda Alfa-1a | peginterferon lambda-1a (Lambda) 180 micrograms by subcutaneous injection for participants who are not infected with SARS-CoV-2~Peginterferon lambda alfa-1a subcutaneous injection: Peginterferon lambda-1a 180 micrograms by subcutaneous injection | 2 | 2 | OG000 |
| Group 2 | Placebo | Placebo (saline) by subcutaneous injection for participants who are not infected with SARS-CoV-2~Saline: Saline subcutaneous injection | 4 | 4 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number of Participants With no Evidence of SARS-CoV-2 Infection
- Description
- Number of participants with no evidence of SARS-CoV-2 infection at or before study day 28.
- Time frame
- Up to 28 days
- Population
Source ClinicalTrials.gov
Trial
- Title
- Peginterferon Lambda-1a for the Prevention and Treatment of SARS-CoV-2 (COVID-19) Infection
- NCT number
- NCT04344600
- Phases
- PHASE2
- Conditions
- Sars-CoV-2 Infection
- Interventions
- Peginterferon lambda alfa-1a subcutaneous injection, Saline
- Lead sponsor
- Johns Hopkins University
- Results first posted
- 2022-07-14
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04344600?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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