Comparison · NCT04392375-7d73ffa1
Nifedipine 30MG vs Placebo: Number of Participants With Hypotension of ≥30% Decrease in Blood Pressure From Baseline Following Acute Antihypertensive Therapy
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Nifedipine 30MG vs Placebo: Number of Participants With Hypotension of ≥30% Decrease in Blood Pressure From Baseline Following Acute Antihypertensive Therapy. Trial comparisons, record NCT04392375-7d73ffa1. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04392375-7d73ffa1
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.444 | 0.246 | 0.663 | wilson | |
| Risk in group 2 | 0.222 | 0.106 | 0.408 | wilson | |
| Risk difference, group 1 minus group 2 | 0.222 | -0.0496 | 0.47 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 2 | 0.834 | 4.8 | log | |
| Odds ratio, group 1 over group 2 | 2.8 | 0.764 | 10.3 | log | |
| Number needed to treat, for one more participant with the outcome on Nifedipine 30MG than on Placebo | 4.5 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Nifedipine 30MG | Oral administration of 30mg Nifedipine XL q24 hours until delivery~Nifedipine 30 MG: Nifedipine XL is a long-acting medication used to lower blood pressure. The investigators want to learn whether women who receive the study drug will experience fewer severe-range blood pressure readings, and therefore need fewer intravenous (IV) medications to safely lower blood pressure. | 8 | 18 | OG000 |
| Group 2 | Placebo | Matching placebo group q24hrs until delivery~Placebos: At the time of enrollment, patients will be randomized to either the study drug (oral Nifedipine XL 30mg) or identical placebo. | 6 | 27 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Hypotension of ≥30% Decrease in Blood Pressure From Baseline Following Acute Antihypertensive Therapy
- Description
- Time frame
- Between enrollment and delivery, assessed up to 18 weeks
- Population
Source ClinicalTrials.gov
Trial
- Title
- Nifedipine XL Versus Placebo for the Treatment of Preeclampsia With Severe Features During Induction of Labor
- NCT number
- NCT04392375
- Phases
- PHASE4
- Conditions
- Preeclampsia Severe
- Interventions
- Nifedipine 30 MG, Placebos
- Lead sponsor
- Ohio State University
- Results first posted
- 2023-07-24
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04392375?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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