Comparison · NCT04402866-e808f5d2
Part 2: TD-0903 - 3 mg vs Part 2: Matching Placebo: Part 2: Number of Participants Alive and Respiratory Failure-free on Day 28
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Part 2: TD-0903 - 3 mg vs Part 2: Matching Placebo: Part 2: Number of Participants Alive and Respiratory Failure-free on Day 28. Trial comparisons, record NCT04402866-e808f5d2. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04402866-e808f5d2
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.868 | 0.79 | 0.92 | wilson | |
| Risk in group 2 | 0.817 | 0.732 | 0.88 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0506 | -0.0489 | 0.15 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.06 | 0.944 | 1.19 | log | |
| Odds ratio, group 1 over group 2 | 1.47 | 0.693 | 3.11 | log | |
| Number needed to treat, for one more participant with the outcome on Part 2: TD-0903 - 3 mg than on Part 2: Matching Placebo | 19.8 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Part 2: TD-0903 - 3 mg | TD-0903 inhalation solution (1 mL) was administered once daily for up to 7 days via oral inhalation using the Aerogen Solo nebulizer system at a dose of 3 mg. Participants were administered a 6 mg loading dose as the total dose on Day 1. | 92 | 106 | OG001 |
| Group 2 | Part 2: Matching Placebo | Matching placebo inhalation solution (1 mL) was administered once daily for up to 7 days via oral inhalation using the Aerogen Solo nebulizer system. | 85 | 104 | OG000 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Part 2: Number of Participants Alive and Respiratory Failure-free on Day 28
- Description
Defined as participants who were alive and did not require the use of any respiratory support (invasive mechanical ventilation, non-invasive positive pressure ventilation, high-flow oxygen devices, or oxygen supplementation) on Day 28.
- Time frame
- Day 28
- Population
- ITT analysis set (Part 2) - all participants with analyzable data who were randomized into the study.
Source ClinicalTrials.gov
Trial
- Title
- TD-0903 for ALI Associated With COVID-19
- NCT number
- NCT04402866
- Phases
- PHASE2
- Conditions
- Acute Lung Injury (ALI) Associated With COVID-19, Lung Inflammation Associated With COVID-19
- Interventions
- TD-0903, Placebo
- Lead sponsor
- Theravance Biopharma
- Results first posted
- 2022-03-17
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04402866?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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