Comparison · NCT04406714-6a78f581
Trial Mailed FIT Intervention - Age Group 50-75 vs Trial Usual Care - Age Group 50-75: Proportion of Subjects Who Completed Colorectal Cancer (CRC) Screening Within 6 Months (Trial - Age Group 50-75)
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Trial Mailed FIT Intervention - Age Group 50-75 vs Trial Usual Care - Age Group 50-75: Proportion of Subjects Who Completed Colorectal Cancer (CRC) Screening Within 6 Months (Trial - Age Group 50-75). Trial comparisons, record NCT04406714-6a78f581. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04406714-6a78f581
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.299 | 0.279 | 0.319 | wilson | |
| Risk in group 2 | 0.096 | 0.0838 | 0.11 | wilson | |
| Risk difference, group 1 minus group 2 | 0.203 | 0.179 | 0.227 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 3.11 | 2.68 | 3.62 | log | |
| Odds ratio, group 1 over group 2 | 4.02 | 3.36 | 4.79 | log | |
| Number needed to treat, for one more participant with the outcome on Trial Mailed FIT Intervention - Age Group 50-75 than on Trial Usual Care - Age Group 50-75 | 4.93 | 4.41 | 5.59 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: usual care.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Trial Mailed FIT Intervention - Age Group 50-75 | Subjects who are between 50-75 years of age and received study intervention.~Trial Mailed FIT Intervention: Subjects are mailed an introductory letter advising them that they will receive a FIT kit in the mail. Next, subjects are mailed a FIT packet in an envelope that contains a cover letter, CRC information sheet, FIT instruction sheet, and FIT kit with a pre-paid return envelope. Subjects receive up to two mailed letters reminding them to complete and return the FIT. Subjects receive FIT results via letter or phone call. | 598 | 2,001 | OG000 |
| Group 2 | Trial Usual Care - Age Group 50-75 | Subjects who are 50-75 years of age and did not receive study intervention. | 192 | 2,001 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Proportion of Subjects Who Completed Colorectal Cancer (CRC) Screening Within 6 Months (Trial - Age Group 50-75)
- Description
The proportion of subjects who received study Intervention (Age Group 50-75) and did not receive study intervention (Usual Care - Age Group 50-75 who completed CRC screening using any of the screening modalities recommended by the United States Preventive Services Task Force per electronic health record review.~Fecal immunochemical test (FIT), fecal occult blood test \[FOBT\], fecal immunochemical test - deoxyribonucleic acid (FIT-DNA), colonoscopy, flexible sigmoidoscopy, flexible sigmoidoscopy with FIT, Computerized Tomography colonography.
- Time frame
- Up to 6 months after randomization
- Population
- Subjects who actively receive health care from the study sites, aged between 50-75.
Source ClinicalTrials.gov
Trial
- Title
- Scaling CRC Screening Through Outreach, Referral, and Engagement (SCORE)
- NCT number
- NCT04406714
- Phases
- NA
- Conditions
- Colorectal Cancer
- Interventions
- Trial Mailed FIT Intervention - Age Group 50-75, Sub-Study Mailed FIT Intervention Enhanced Envelope - Age Group 45-49, Sub-Study Mailed FIT Active Comparator Plain Envelope - Age Group 45-49
- Lead sponsor
- UNC Lineberger Comprehensive Cancer Center
- Results first posted
- 2024-06-25
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04406714?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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