Comparison · NCT04412057-9bacb785
CERC-002 vs Placebo: Number of Subjects Alive and Free of Respiratory Failure
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. CERC-002 vs Placebo: Number of Subjects Alive and Free of Respiratory Failure. Trial comparisons, record NCT04412057-9bacb785. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04412057-9bacb785
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.839 | 0.674 | 0.929 | wilson | |
| Risk in group 2 | 0.645 | 0.469 | 0.789 | wilson | |
| Risk difference, group 1 minus group 2 | 0.194 | -0.0253 | 0.391 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.3 | 0.96 | 1.76 | log | |
| Odds ratio, group 1 over group 2 | 2.86 | 0.855 | 9.56 | log | |
| Number needed to treat, for one more participant with the outcome on CERC-002 than on Placebo | 5.17 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | CERC-002 | CERC-002: Administered once subcutaneously at 16 mg/kg dose up to a maximum dose of 1200 mg. | 26 | 31 | OG000 |
| Group 2 | Placebo | Placebo: Administered once subcutaneously | 20 | 31 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number of Subjects Alive and Free of Respiratory Failure
- Description
Respiratory failure defined based on resource utilization requiring at least one of the following:~* Endotracheal intubation and mechanical ventilation~* Oxygen delivered by high-flow nasal cannula (heated, humidified oxygen delivered via reinforced nasal cannula at flow rates \>20L/min with fraction of delivered oxygen ≥0.5)~* Noninvasive positive pressure ventilation,~* Extracorporeal membrane oxygenation
- Time frame
- Baseline to Day 28
- Population
The number of subjects alive and free of respiratory failure up to Day 28/Early Termination (ET). The study was designed with broad eligibility criteria allowing patients who received high-flow oxygen or positive-pressure oxygen prior to dosing to be enrolled. As overlap was expected patients who were in respiratory failure before dosing or who required elevation in their ventilation support were excluded from the primary analysis (N=20, 9 CERC-002 patients and 11 placebo patients).
Source ClinicalTrials.gov
Trial
- Title
- Clinical Trial to Evaluate CERC-002 in Adults With COVID-19 Pneumonia and Acute Lung Injury
- NCT number
- NCT04412057
- Phases
- PHASE2
- Conditions
- COVID-19 Pneumonia, Acute Lung Injury, ARDS
- Interventions
- CERC-002, Placebo
- Lead sponsor
- Aevi Genomic Medicine, LLC, a Cerecor company
- Results first posted
- 2022-03-04
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04412057?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
The record is JSON. No key.
GET https://conductscience.org/api/comparisons/v1/NCT04412057-9bacb785