Comparison · NCT04424901-sae
Standard Care With Dipyridamole vs Standard Care: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Standard Care With Dipyridamole vs Standard Care: serious adverse events. Trial comparisons, record NCT04424901-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04424901-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.35 | 0.181 | 0.567 | wilson | |
| Risk in group 2 | 0.238 | 0.106 | 0.451 | wilson | |
| Risk difference, group 1 minus group 2 | 0.112 | -0.16 | 0.366 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.47 | 0.557 | 3.88 | log | |
| Odds ratio, group 1 over group 2 | 1.72 | 0.442 | 6.72 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Standard Care With Dipyridamole than on Standard Care | 8.94 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: standard care.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Standard Care With Dipyridamole | For this arm, Dipyridamole 100 mg, tid is given for 7 days. Hospitalized patients meeting screen criteria receive standard Hospital care from which clinical event and lab data are collected.~Day 3,6 \& 9 research samples will be used for obtaining immunological profiles as well as metabolomic profiling and whole genome sequencing for discovery of new biomarkers/ genomic regions that confer increased susceptibility to infection and DIP treatment efficacy or safety. Other samples will be obtained for microbiome and viral analyses.~Data collection ends on day 9.~Dipyridamole: Dipyridamole-100mg taken 3 times a day by mouth for 7 days. | 7 | 20 | EG001 |
| Group 2 | Standard Care | Hospitalized patients meeting screen criteria receive standard Hospital care from which clinical event and lab data are collected.~Day 3,6 \& 9 research samples will be used for obtaining immunological profiles as well as metabolomic profiling and whole genome sequencing for discovery of new biomarkers/ genomic regions that confer increased susceptibility to infection and DIP treatment efficacy or safety. Other samples will be obtained for microbiome and viral analyses.~Data collection ends on day 9. | 5 | 21 | EG000 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Mortality assessed up to 30 days beyond date of enrollment
Source ClinicalTrials.gov
Trial
- Title
- Trial of Open Label Dipyridamole- In Hospitalized Patients With COVID-19
- NCT number
- NCT04424901
- Phases
- PHASE2
- Conditions
- COVID-19 Pneumonia, Vascular Complications
- Interventions
- Placebo, Dipyridamole Tablets
- Lead sponsor
- UConn Health
- Results first posted
- 2023-04-21
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04424901?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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