Comparison · NCT04442269-sae
Dupilumab 300 mg Q2W vs Placebo: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Dupilumab 300 mg Q2W vs Placebo: serious adverse events. Trial comparisons, record NCT04442269-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04442269-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0857 | 0.0296 | 0.224 | wilson | |
| Risk in group 2 | 0.185 | 0.0818 | 0.367 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0995 | -0.29 | 0.073 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.463 | 0.121 | 1.77 | log | |
| Odds ratio, group 1 over group 2 | 0.413 | 0.0892 | 1.91 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Dupilumab 300 mg Q2W than on Placebo | 10.1 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Dupilumab 300 mg Q2W | Subcutaneous (SC) dose every two weeks (Q2W) | 3 | 35 | EG001 |
| Group 2 | Placebo | Matching dupilumab without active substance | 5 | 27 | EG000 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- From Day 1 to EOS (End Of Study) visit ~(up to 64 weeks)
Source ClinicalTrials.gov
Trial
- Title
- Investigating Treatment With Dupilumab in Patients With Allergic Bronchopulmonary Aspergillosis (ABPA) (LIBERTY ABPA AIRED)
- NCT number
- NCT04442269
- Phases
- PHASE2
- Conditions
- Allergic Bronchopulmonary Aspergillosis
- Interventions
- dupilumab, Placebo
- Lead sponsor
- Regeneron Pharmaceuticals
- Results first posted
- 2024-08-21
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04442269?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
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GET https://conductscience.org/api/comparisons/v1/NCT04442269-sae