Comparison · NCT04445792-deaths
Immediate Pharmacogenetics (PGx) Guided Therapy vs Delayed Pharmacogenetics (PGx) Testing: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Immediate Pharmacogenetics (PGx) Guided Therapy vs Delayed Pharmacogenetics (PGx) Testing: deaths from any cause. Trial comparisons, record NCT04445792-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04445792-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.00243 | 0.00104 | 0.00568 | wilson | |
| Risk in group 2 | 0.00341 | 0.00165 | 0.00701 | wilson | |
| Risk difference, group 1 minus group 2 | -0.000973 | -0.00484 | 0.00272 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.714 | 0.227 | 2.25 | log | |
| Odds ratio, group 1 over group 2 | 0.714 | 0.226 | 2.25 | log | |
| Number needed to treat, for one fewer death from any cause on Immediate Pharmacogenetics (PGx) Guided Therapy than on Delayed Pharmacogenetics (PGx) Testing | 1,030 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Immediate Pharmacogenetics (PGx) Guided Therapy | Acute Pain Trial: Immediate pharmacogenetic testing and genotype-guided post-surgical opioid therapy (Intervention arm).~Chronic Pain Trial: Immediate pharmacogenetic testing and genotype-guided opioid therapy (Intervention arm).~Depression: Immediate pharmacogenetic testing and genotype-guided anti-depressant therapy (Intervention arm). | 5 | 2,055 | EG000 |
| Group 2 | Delayed Pharmacogenetics (PGx) Testing | Acute Pain Trial: Standard care and pharmacogenetic testing after 6 months (Control arm).~Chronic Pain Trial: Standard care with 6-month delayed pharmacogenetic testing (Control arm).~Depression: Standard care with 6-month delayed pharmacogenetic testing (Control arm). | 7 | 2,055 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
- Approximately 6 months
Source ClinicalTrials.gov
Trial
- Title
- A Depression and Opioid Pragmatic Trial in Pharmacogenetics (DCRI Coordinating Center)
- NCT number
- NCT04445792
- Phases
- NA
- Conditions
- Depression, Acute Pain, Chronic Pain
- Interventions
- Pharmacogenetic testing, Clinical decisions support
- Lead sponsor
- Duke University
- Results first posted
- 2025-01-06
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04445792?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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