Comparison · NCT04452344-5bf7d392
Non-Opioid vs Opioid: Number of Participants Receiving Rescue Medication
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Non-Opioid vs Opioid: Number of Participants Receiving Rescue Medication. Trial comparisons, record NCT04452344-5bf7d392. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04452344-5bf7d392
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0286 | 0.0196 | 0.0416 | wilson | |
| Risk in group 2 | 0.0596 | 0.046 | 0.077 | wilson | |
| Risk difference, group 1 minus group 2 | -0.031 | -0.0506 | -0.0122 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.48 | 0.303 | 0.759 | log | |
| Odds ratio, group 1 over group 2 | 0.465 | 0.288 | 0.749 | log | |
| Number needed to treat, for one fewer participant with the outcome on Non-Opioid than on Opioid | 32.3 | 19.8 | 82.1 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Non-Opioid | Combination of ibuprofen 400 mg/acetaminophen 500 mg~two over-the-counter analgesics: combination of over-the-counter analgesics (ibuprofen/acetaminophen) | 26 | 909 | OG000 |
| Group 2 | Opioid | Combination analgesic of hydrocodone 5mg/acetaminophen 300 mg and a placebo pill.~opioid-containing analgesic: hydrocodone/ acetaminophen combination product | 54 | 906 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants Receiving Rescue Medication
- Description
- Participant receiving additional pain medication (oxycodone) as study analgesic is not managing pain sufficiently
- Time frame
- At post operative visit (9 days after surgery +/- 5 days)
- Population
Source ClinicalTrials.gov
Trial
- Title
- Opioid Analgesic Reduction Study
- NCT number
- NCT04452344
- Phases
- PHASE3
- Conditions
- Opioid Use
- Interventions
- opioid-containing analgesic, two over-the-counter analgesics
- Lead sponsor
- Rutgers, The State University of New Jersey
- Results first posted
- 2024-07-30
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04452344?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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