Comparison · NCT04468776-697aa087
Medication (Zolpidem or Trazodone) vs Combination: Medication Adherence
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Medication (Zolpidem or Trazodone) vs Combination: Medication Adherence. Trial comparisons, record NCT04468776-697aa087. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04468776-697aa087
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.844 | 0.712 | 0.923 | wilson | |
| Risk in group 2 | 0.636 | 0.489 | 0.762 | wilson | |
| Risk difference, group 1 minus group 2 | 0.208 | 0.0255 | 0.375 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.33 | 1.03 | 1.71 | log | |
| Odds ratio, group 1 over group 2 | 3.1 | 1.13 | 8.55 | log | |
| Number needed to treat, for one more participant with the outcome on Medication (Zolpidem or Trazodone) than on Combination | 4.81 | 2.67 | 39.2 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Medication (Zolpidem or Trazodone) | Zolpidem or trazodone, as prescribed by physician~Zolpidem: Zolpidem, as prescribed by physician~Trazodone: Trazodone, as prescribed by physician | 38 | 45 | OG000 |
| Group 2 | Combination | Medication (zolpidem or trazodone) as prescribed by physician and Internet-based CBT-I program~Zolpidem: Zolpidem, as prescribed by physician~Internet Cognitive Behavioral Therapy for Insomnia (CBT-I): 6-week internet CBT-I multi-component intervention (SHUTi) including sleep restriction, stimulus control, cognitive restructuring, sleep behaviors, and relapse prevention~Trazodone: Trazodone, as prescribed by physician | 28 | 44 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- OTHER_PRE_SPECIFIED
- Title
- Medication Adherence
- Description
Medication use is assessed using self-reported prescription, over-the-counter, and supplement name and frequency. Count of participants reporting zolpidem or trazodone use for sleep is recorded for adherence to the Medication and Combination treatment arms.
- Time frame
- 1 month, 9 weeks, 6 months, 9 months, 12 months
- Population
- Participants included if they completed the 1 month, 9 weeks, 6 month or 12 month follow-up assessment medications questions.
Source ClinicalTrials.gov
Trial
- Title
- CBT-I or Zolpidem/Trazodone for Insomnia
- NCT number
- NCT04468776
- Phases
- PHASE4
- Conditions
- Chronic Insomnia
- Interventions
- Zolpidem, Internet Cognitive Behavioral Therapy for Insomnia (CBT-I), Trazodone
- Lead sponsor
- California Pacific Medical Center Research Institute
- Results first posted
- 2025-02-24
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04468776?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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