Comparison · NCT04497142-5a7f6896
Perampanel + Electrocorticography vs Standard of Care + Electrocorticography: Seizure-freedom
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Perampanel + Electrocorticography vs Standard of Care + Electrocorticography: Seizure-freedom. Trial comparisons, record NCT04497142-5a7f6896. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04497142-5a7f6896
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.143 | 0.0257 | 0.513 | wilson | |
| Risk in group 2 | 0.5 | 0.15 | 0.85 | wilson | |
| Risk difference, group 1 minus group 2 | -0.357 | -0.726 | 0.152 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.286 | 0.0363 | 2.25 | log | |
| Odds ratio, group 1 over group 2 | 0.167 | 0.00931 | 2.98 | log | |
| Number needed to treat, for one fewer participant with the outcome on Perampanel + Electrocorticography than on Standard of Care + Electrocorticography | 2.8 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Perampanel + Electrocorticography | Perampanel 6mg on day prior to resection, 4mg pre-op prior to resection, and 4mg daily until PD or up to 12 months. Intraoperative ECoG with 20 contact subdural grid performed for analysis of high frequency oscillation (80-500 Hz) rate. | 1 | 7 | OG000 |
| Group 2 | Standard of Care + Electrocorticography | Levetiracetam peri-operatively per standard of care. Intraoperative ECoG with 20 contact subdural grid performed for analysis of high frequency oscillation (80-500 Hz) rate. | 2 | 4 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Seizure-freedom
- Description
- Seizure-free rates were assessed from the time of initial glioma resection to radiographic tumor progression or up to a maximum of 12 months.
- Time frame
- From time of initial surgery to PD or up to 12 months
- Population
Source ClinicalTrials.gov
Trial
- Title
- Effect of Perampanel on Peritumoral Hyperexcitability in HGG
- NCT number
- NCT04497142
- Phases
- PHASE1, PHASE2
- Conditions
- Glioma, Malignant, Surgery, Seizures
- Interventions
- Perampanel, Standard of Care
- Lead sponsor
- Dana-Farber Cancer Institute
- Results first posted
- 2024-08-05
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04497142?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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