Comparison · NCT04514458-5aedd1b7
EHR-based Alert vs Usual Care: Percentage of Patients on ARNIs
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. EHR-based Alert vs Usual Care: Percentage of Patients on ARNIs. Trial comparisons, record NCT04514458-5aedd1b7. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04514458-5aedd1b7
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.488 | 0.45 | 0.525 | wilson | |
| Risk in group 2 | 0.456 | 0.417 | 0.495 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0316 | -0.0225 | 0.0854 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.07 | 0.953 | 1.2 | log | |
| Odds ratio, group 1 over group 2 | 1.14 | 0.913 | 1.41 | log | |
| Number needed to treat, for one more participant with the outcome on EHR-based Alert than on Usual Care | 31.7 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: usual care.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | EHR-based Alert | Providers will receive a best practice alert for each of their eligible patients upon opening of the order entry screen in the patient's medical record. The alert will inform the provider to the presence of HFrEF and of the patient's current left ventricular ejection fraction and current evidence-based medications for HFrEF. It will also provide access to an order set with recommended evidence-based HFrEF therapies as well as a link to the best available guideline-recommended information regarding the treatment of heart failure.~Best practice alert for the notification of patient HFrEF and recommended evidence-based therapies (NO drugs are being administered in this trial): Providers will receive a best practice alert for each of their eligible patients upon opening of the order entry screen in the patient's medical record. The alert will inform the provider to the presence of HFrEF and of the patient's current left ventricular ejection fraction and current evidence-based medications for HFrEF. It will also provide access to an order set with recommended evidence-based HFrEF therapies as well as a link to the best available guideline-recommended information regarding the treatment of heart failure. | 334 | 685 | OG000 |
| Group 2 | Usual Care | Providers will not receive an alert and will proceed with usual care. | 285 | 625 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Percentage of Patients on ARNIs
- Description
- Assessed as the number of patients with a prescribed ARNI
- Time frame
- Assessed from the date of randomization to 30 days post-randomization
- Population
Source ClinicalTrials.gov
Trial
- Title
- Pragmatic Trial of Messaging to Providers About Treatment of Heart Failure
- NCT number
- NCT04514458
- Phases
- NA
- Conditions
- Heart Failure With Reduced Ejection Fraction
- Interventions
- Best practice alert for the notification of patient HFrEF and recommended evidence-based therapies (NO drugs are being administered in this trial)
- Lead sponsor
- Yale University
- Results first posted
- 2025-07-01
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04514458?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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